Evidence map›Paper›PMID 26459423›Full record

ArticleHypertension (Dallas, Tex. : 1979)2015

Sex-Specific Effect of Endothelin in the Blood Pressure Response to Acute Angiotensin II in Growth-Restricted Rats.

Suttira Intapad, Norma B Ojeda, Elliott Varney, Thomas P Royals, Barbara T Alexander

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Hypertension (Dallas, Tex. : 1979), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
2.9field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 16 citations in OpenAlex.

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  12. Gender Differences in Hypertension.Journal of cardiovascular translational research · 2020
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 2 countries.

Suttira IntapadDepartment of Pediatrics (N.B.O.), Department of Physiology and Biophysics (S.I., N.B.O., E.V., T.P.R., B.T.A.), and the Center for Developmental Disorders Research (S.I., N.B.O., B.T.A.), University of Mississippi Medical Center, Jackson.
Norma B OjedaDepartment of Pediatrics (N.B.O.), Department of Physiology and Biophysics (S.I., N.B.O., E.V., T.P.R., B.T.A.), and the Center for Developmental Disorders Research (S.I., N.B.O., B.T.A.), University of Mississippi Medical Center, Jackson.
Elliott VarneyDepartment of Pediatrics (N.B.O.), Department of Physiology and Biophysics (S.I., N.B.O., E.V., T.P.R., B.T.A.), and the Center for Developmental Disorders Research (S.I., N.B.O., B.T.A.), University of Mississippi Medical Center, Jackson.
Thomas P RoyalsDepartment of Pediatrics (N.B.O.), Department of Physiology and Biophysics (S.I., N.B.O., E.V., T.P.R., B.T.A.), and the Center for Developmental Disorders Research (S.I., N.B.O., B.T.A.), University of Mississippi Medical Center, Jackson.
Barbara T AlexanderDepartment of Pediatrics (N.B.O.), Department of Physiology and Biophysics (S.I., N.B.O., E.V., T.P.R., B.T.A.), and the Center for Developmental Disorders Research (S.I., N.B.O., B.T.A.), University of Mississippi Medical Center, Jackson. balexander@umc.edu.
University of Mississippi Medical Center · US

Funding

STRUCTURAL VASCULAR ADAPTATION OF THE MICROCIRCULATIONP01HL051971 · NHLBI · UNIVERSITY OF MISSISSIPPI MEDICAL CENTER · PI RECKELHOFF, JANE F · 1993 to 2018
$39.4M
The role of leptin in autoimmune-associated hypertensionP20GM104357 · NIGMS · UNIVERSITY OF MISSISSIPPI MED CTR · PI TAYLOR, ERIN BASSFORD · 2013 to 2022
$23.4M
Low birth weight, the kidney, and hypertensionR01HL074927 · NHLBI · UNIVERSITY OF MISSISSIPPI MEDICAL CENTER · PI ALEXANDER, BARBARA T · 2004 to 2013
$3.0M
CARDIOVASCULAR/RENAL MECHANISMS OF HYPERTENSIONF32HL010137 · NHLBI · UNIVERSITY OF MISSISSIPPI MEDICAL CENTER · PI ALEXANDER, BARBARA T · 1999 to 2001
$80k
NHLBI NIH HHS F32 HL010137NHLBI NIH HHS HL074927NHLBI NIH HHS HL51971NHLBI NIH HHS P01 HL051971NHLBI NIH HHS R01 HL074927NIGMS NIH HHS P20 GM104357NIGMS NIH HHS P20GM104357
6 · The paper itself

Abstract

The renal endothelin system contributes to sex differences in blood pressure with males demonstrating greater endothelin type-A receptor-mediated responses relative to females. Intrauterine growth restriction programs hypertension and enhance renal sensitivity to acute angiotensin II in male growth-restricted rats. Endothelin is reported to work synergistically with angiotensin II. Thus, this study tested the hypothesis that endothelin augments the blood pressure response to acute angiotensin II in male growth-restricted rats. Systemic and renal hemodynamics were determined in response to acute angiotensin II (100 mg/kg per minute for 30 minutes) with and without the endothelin type-A receptor antagonist, Atrasentan (ABT-627; 10 ng/kg per minute for 30 minutes), in rats pretreated with enalapril (250 mg/L for 1 week) to normalize the endogenous renin-angiotensin system. Endothelin type-A receptor blockade reduced angiotensin II-mediated increases in blood pressure in male control and male growth-restricted rats. Endothelin type-A receptor blockade also abolished hyper-responsiveness to acute angiotensin II in male growth-restricted rats. Yet, blood pressure remained significantly elevated above baseline after endothelin type-A receptor blockade, suggesting that factors in addition to endothelin contribute to the basic angiotensin II-induced pressor response in male rats. We also determined sex-specific effects of endothelin on acute angiotensin II-mediated hemodynamic responses. Endothelin type-A receptor blockade did not reduce acute angiotensin II-mediated increases in blood pressure in female control or growth-restricted rats, intact or ovariectomized. Thus, these data suggest that endothelin type-A receptor blockade contributes to hypersensitivity to acute angiotensin II in male growth-restricted rats and further supports the sex-specific effect of endothelin on blood pressure.

Indexed as

Angiotensin-Converting Enzyme InhibitorsAngiotensin IIAnimalsAtrasentanBlood PressureBlotting, WesternEnalaprilEndothelin-1Endothelin Receptor AntagonistsFemaleFetal Growth RetardationGlomerular Filtration RateHemodynamicsKidneyMaleOvariectomyAngiotensin-Converting Enzyme InhibitorsAngiotensin IIAtrasentanEnalaprilEndothelin-1Endothelin Receptor AntagonistsPyrrolidinesReceptor, Endothelin AReceptor, Endothelin Bangiotensin IIblood pressureendothelinsrenin–angiotensin systemsex characteristics

Identifiers

PMID26459423
PMCPMC4656137
OpenAlexW2151204220

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.