Evidence map›Paper›PMID 26459312›Full record

ArticleTumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine2016

Evaluation of cannabinoid CB1 and CB2 receptors expression in mobile tongue squamous cell carcinoma: associations with clinicopathological parameters and patients' survival.

Stamatios Theocharis, Constantinos Giaginis, Paraskevi Alexandrou, Jose Rodriguez, Jason Tasoulas, Eugene Danas, Efstratios Patsouris, Jerzy Klijanienko

Abstract read
PubMed Publisher
In one paragraph

Article in Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it, 26 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Review
  5. Review
  6. Review
  7. Review
  8. Article
  9. Cannabinoids Promote Progression of HPV-Positive Head and Neck Squamous Cell Carcinoma via p38 MAPK Activation.Clinical cancer research : an official journal of the American Association for Cancer Research · 2020
    Article
  10. Review
  11. Review
  12. Endocannabinoids as Guardians of Metastasis.International journal of molecular sciences · 2016
    Review
  13. Article
  14. Unleashing the therapeutic role of cannabidiol in dentistry.Journal of oral biology and craniofacial research
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Stamatios TheocharisFirst Department of Pathology, Medical School, University of Athens, 75 M. Asias str., Goudi, Athens, Greece, GR11527. statheocharis@yahoo.com.
Constantinos GiaginisFirst Department of Pathology, Medical School, University of Athens, 75 M. Asias str., Goudi, Athens, Greece, GR11527.
Paraskevi AlexandrouFirst Department of Pathology, Medical School, University of Athens, 75 M. Asias str., Goudi, Athens, Greece, GR11527.
Jose RodriguezDepartment of Head and Neck Surgery, Institut Curie, Paris, France.
Jason TasoulasFirst Department of Pathology, Medical School, University of Athens, 75 M. Asias str., Goudi, Athens, Greece, GR11527.
Eugene DanasFirst Department of Pathology, Medical School, University of Athens, 75 M. Asias str., Goudi, Athens, Greece, GR11527.
Efstratios PatsourisFirst Department of Pathology, Medical School, University of Athens, 75 M. Asias str., Goudi, Athens, Greece, GR11527.
Jerzy KlijanienkoDepartment of Pathology, Institut Curie, Paris, France.
National and Kapodistrian University of Athens · GRInstitut Curie · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cannabinoid receptors (CB1R and CB2R) constitute essential members of the endocannabinoid system (ECS) which participates in many different functions indispensable to homeostatic regulation in several tissues, exerting also antitumorigenic effects. The present study aimed to assess the clinical significance of CB1R and CB2R protein expression in mobile tongue squamous cell carcinoma (SCC). CB1R and CB2R expression was assessed immunohistochemically on 28 mobile tongue SCC tissue samples and was analyzed in relation with clinicopathological characteristics and overall and disease-free patients' survival. CB1R, CB2R, and concomitant CB1R/CB2R expression was significantly increased in older compared to younger mobile tongue SCC patients (p = 0.0243, p = 0.0079, and p = 0.0366, respectively). Enhanced CB2R and concomitant CB1R/CB2R expression was significantly more frequently observed in female compared to male mobile tongue SCC patients (p = 0.0025 and p = 0.0016, respectively). Elevated CB2R expression was significantly more frequently observed in mobile tongue SCC patients presenting well-defined tumor shape compared to those with diffuse (p = 0.0430). Mobile tongue SCC patients presenting enhanced CB1R, CB2R, or concomitant CB1R/CB2R expression showed significantly longer overall (log-rank test, p = 0.004, p = 0.011, p = 0.018, respectively) and disease-free (log-rank test, p = 0.003, p = 0.007, p = 0.027, respectively) survival times compared to those with low expression. In multivariate analysis, CB1R was identified as an independent prognostic factor for disease-free patients' survival (Cox-regression analysis, p = 0.032). The present study provides evidence that CB1R and CB2R may play a role in the pathophysiological aspects of the mobile tongue SCC and even each molecule may constitute a potential target for the development of novel anti-cancer drugs for this type of malignancy.

Indexed as

AdultAgedAged, 80 and overAge FactorsBiomarkers, TumorCarcinoma, Squamous CellFemaleHumansImmunohistochemistryKaplan-Meier EstimateMaleMiddle AgedMultivariate AnalysisOutcome Assessment, Health CarePrognosisProportional Hazards ModelsBiomarkers, TumorReceptor, Cannabinoid, CB1Receptor, Cannabinoid, CB2Cannabinoid receptorsClinicopathological parametersImmunohistochemistryMobile tongue squamous cell carcinomaPrognosis

Identifiers

PMID26459312
OpenAlexW1947263147

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.