ArticleEnvironmental health and preventive medicine2016
Metabolomic profiling reveals novel biomarkers of alcohol intake and alcohol-induced liver injury in community-dwelling men.
Article in Environmental health and preventive medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 57 papers, 1 of them a synthesis that pooled it.
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Who cites it
57 citing papers in PubMed, 1 synthesis or guideline pooled it, 102 citations in OpenAlex.
- Metabolic profiling of alcohol consumption in 9778 young adults.International journal of epidemiology · 2016Pooled it
- A capillary electrophoresis coupled to mass spectrometry pipeline for long term comparable assessment of the urinary metabolome.Scientific reports · 2016Trial
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- Cardiovascular Risk of Alcohol Consumption due to Renal Impairment: A 10-Year Prospective Study in a Community-Dwelling Japanese Population.Journal of atherosclerosis and thrombosis · 2026Article
- Associations of coffee, alcohol, medication and supplement use with the metabolome and lipidome: an observational study of premenopausal women.Metabolomics : Official journal of the Metabolomic Society · 2026Observational
- The Hepatoprotective Properties of the Revised Formulation of Dahuang Xiaoshi Tang, an Ancient Chinese Herbal Decoction, Are Probed by Integrated Metabolomics and Network Pharmacology.Pharmaceuticals (Basel, Switzerland) · 2025Article
- Integrated Multiomics Analyses of the Molecular Landscape of Sarcopenia in Alcohol-Related Liver Disease.Journal of cachexia, sarcopenia and muscle · 2025Article
- Reproducibility and validity of a food frequency questionnaire for nutrient intakes in the study areas of large-scale cohort studies in Japan.Nagoya journal of medical science · 2025Article
- Clustering-Based Identification of BMI-Associated Metabolites with Mechanistic Insights from Network Analysis in Korean Men.Metabolites · 2025Article
- Uncovering the sex steroid hormone secrets in alcohol.Alcohol, clinical & experimental research · 2025Article
- Adolescent intermittent ethanol exposure induces sex-specific and time-dependent changes in affective behaviors and metabolomic profiles.Frontiers in behavioral neuroscience · 2025Article
- Article
- Metabolomics Profiles Alterations in Cigarette Smokers and Heated Tobacco Product Users.Journal of epidemiology · 2024Article
- Association of Nonalcoholic Fatty Liver Disease with Arterial Stiffness and its Metabolomic Profiling in Japanese Community-Dwellers.Journal of atherosclerosis and thrombosis · 2024Article
- A population-based urinary and plasma metabolomics study of environmental exposure to cadmium.Environmental health and preventive medicine · 2024Article
- An epidemiological introduction to human metabolomic investigations.Trends in endocrinology and metabolism: TEM · 2023Review
- Difference and clinical value of metabolites in plasma and feces of patients with alcohol-related liver cirrhosis.World journal of gastroenterology · 2023Article
- Quality Control of Targeted Plasma Lipids in a Large-Scale Cohort Study Using Liquid Chromatography-Tandem Mass Spectrometry.Metabolites · 2023Article
- Metabolomics analysis of urine from patients with alcohol-associated liver disease reveals dysregulated caffeine metabolism.American journal of physiology. Gastrointestinal and liver physiology · 2023Article
- Article
Corrections and comments
- Erratum issued
Authors and funding
16 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveMetabolomics is a promising approach to the identification of biomarkers in plasma. Here, we performed a population-based, cross-sectional study to identify potential biomarkers of alcohol intake and alcohol-induced liver injury by metabolomic profiling using capillary electrophoresis-mass spectrometry (CE-MS).
methodsFasting plasma samples were collected from 896 Japanese men who participated in the baseline survey of the Tsuruoka Metabolomics Cohort Study, and 115 polar metabolites were identified and absolutely quantified by CE-MS. Information on daily ethanol intake was collected through a standardized, self-administered questionnaire. The associations between ethanol intake and plasma concentration of metabolites were examined. Relationships between metabolite concentrations or their ratios and serum liver enzyme levels in the highest ethanol intake group (>46.0 g/day) were then examined by linear regression analysis. Replication analysis was conducted in 193 samples collected from independent population of this cohort.
resultsNineteen metabolites were identified to have an association with daily alcohol consumption both in the original and replication population. Three of these metabolites (threonine, glutamine, and guanidinosuccinate) were found to associate well with elevated levels of serum liver enzymes in the highest ethanol intake group, but not in the non-drinker group. We also found that the glutamate/glutamine ratio had a much stronger relation to serum γ-glutamyltransferase, aspartate transaminase, and alanine transaminase than glutamate or glutamine alone (standardized beta = 0.678, 0.558, 0.498, respectively).
conclusionsWe found 19 metabolites associated with alcohol intake, and three biomarker candidates (threonine, guanidinosuccinate and glutamine) of alcohol-induced liver injury. Glutamate/glutamine ratio might also be good biomarker.
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