ArticleScientific reports2015
Determining Associations between Human Diseases and non-coding RNAs with Critical Roles in Network Control.
Article in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Insight into the emerging role of long non-coding RNAs in BRAF inhibitor resistance in melanoma.Frontiers in oncology · 2026Review
- A practically efficient algorithm for identifying critical control proteins in directed probabilistic biological networks.NPJ systems biology and applications · 2024Article
- Measuring criticality in control of complex biological networks.NPJ systems biology and applications · 2024Article
- Domination based classification algorithms for the controllability analysis of biological interaction networks.Scientific reports · 2022Article
- Circular RNA circ_0006948 Promotes Esophageal Squamous Cell Carcinoma Progression by Regulating microRNA-3612/LASP1 Axis.Digestive diseases and sciences · 2022Article
- Probabilistic Critical Controllability Analysis of Protein Interaction Networks Integrating Normal Brain Ageing Gene Expression Profiles.International journal of molecular sciences · 2021Article
- Exosomes Mediated Transfer of Circ_0000337 Contributes to Cisplatin (CDDP) Resistance of Esophageal Cancer by Regulating JAK2 via miR-377-3p.Frontiers in cell and developmental biology · 2021Article
- The Emerging Role and Promise of Circular RNAs in Obesity and Related Metabolic Disorders.Cells · 2020Review
- Probabilistic controllability approach to metabolic fluxes in normal and cancer tissues.Nature communications · 2019Article
- Network controllability analysis of intracellular signalling reveals viruses are actively controlling molecular systems.Scientific reports · 2019Article
- Finding and analysing the minimum set of driver nodes required to control multilayer networks.Scientific reports · 2019Article
- Transcriptomic analysis reveals that enterovirus F strain SWUN-AB001 infection activates JNK/SAPK and p38 MAPK signaling pathways in MDBK cells.BMC veterinary research · 2018Article
- NR2C2-uORF targeting UCA1-miR-627-5p-NR2C2 feedback loop to regulate the malignant behaviors of glioma cells.Cell death & disease · 2018Article
- TTBK2 circular RNA promotes glioma malignancy by regulating miR-217/HNF1β/Derlin-1 pathway.Journal of hematology & oncology · 2017Article
- Role of the long non-coding RNA PVT1 in the dysregulation of the ceRNA-ceRNA network in human breast cancer.PloS one · 2017Article
- Identification of genes and critical control proteins associated with inflammatory breast cancer using network controllability.PloS one · 2017Article
- Advances in understanding - genetic basis of intellectual disability.F1000Research · 2016Review
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Deciphering the association between life molecules and human diseases is currently an important task in systems biology. Research over the past decade has unveiled that the human genome is almost entirely transcribed, producing a vast number of non-protein-coding RNAs (ncRNAs) with potential regulatory functions. More recent findings suggest that many diseases may not be exclusively linked to mutations in protein-coding genes. The combination of these arguments poses the question of whether ncRNAs that play a critical role in network control are also enriched with disease-associated ncRNAs. To address this question, we mapped the available annotated information of more than 350 human disorders to the largest collection of human ncRNA-protein interactions, which define a bipartite network of almost 93,000 interactions. Using a novel algorithmic-based controllability framework applied to the constructed bipartite network, we found that ncRNAs engaged in critical network control are also statistically linked to human disorders (P-value of P = 9.8 × 10(-109)). Taken together, these findings suggest that the addition of those genes that encode optimized subsets of ncRNAs engaged in critical control within the pool of candidate genes could aid disease gene prioritization studies.
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