Evidence map›Paper›PMID 26459007›Full record

ReviewEuropean archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery2016

Incidental findings of thyroid tissue in cervical lymph nodes: old controversy not yet resolved?

Asterios Triantafyllou, Michelle D Williams, Peter Angelos, Jatin P Shah, William H Westra, Jennifer L Hunt, Kenneth O Devaney, Alessandra Rinaldo, Pieter J Slootweg, Douglas R Gnepp and 2 more

Open access · greenAbstract readReview
In one paragraph

Review in European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 37 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Article
  6. Review
  7. Review
  8. Article
  9. T1 and T2 mapping for identifying malignant lymph nodes in head and neck squamous cell carcinoma.Cancer imaging : the official publication of the International Cancer Imaging Society · 2023
    Article
  10. Article
  11. Article
  12. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 11 institutions in 4 countries.

Asterios TriantafyllouOral and Maxillofacial Pathology, School of Dentistry, University of Liverpool and Pathology Department, Liverpool Clinical Laboratories, Liverpool, UK.
Michelle D WilliamsDepartment of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Peter AngelosDepartment of Surgery, The University of Chicago Medicine, Chicago, IL, USA.
Jatin P ShahHead and Neck Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
William H WestraDepartments of Pathology and Otolaryngology-Head and Neck Surgery, The Johns Hopkins Medical Institutions, Baltimore, MD, USA.
Jennifer L HuntDepartment of Pathology, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
Kenneth O DevaneyDepartment of Pathology, Allegiance Health, Jackson, MI, USA.
Alessandra RinaldoUniversity of Udine School of Medicine, Udine, Italy.
Pieter J SlootwegDepartment of Pathology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands.
Douglas R GneppUniversity Pathologists, Providence, RI and Fall River, MA, USA.
Carl SilverDepartments of Surgery and Otolaryngology-Head and Neck Surgery, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, NY, USA.
Alfio FerlitoCoordinator of the International Head and Neck Scientific Group, Padua, Italy. a.ferlito@uniud.it.
Albert Einstein College of Medicine · USHenry Ford Allegiance Health · USJohns Hopkins University · USMemorial Sloan Kettering Cancer Center · USProvidence College · USRadboud University Nijmegen · NLThe University of Texas MD Anderson Cancer Center · USUniversity of Arkansas for Medical Sciences · USUniversity of Chicago · USUniversity of Liverpool · GBUniversity of Udine · IT

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Nicholas D Socci · 1985 to 2026
$347.4M
NCI NIH HHS P30 CA008748
6 · The paper itself

Abstract

The clinical significance of papillary or follicular thyroid tissue incidentally discovered in cervical lymph nodes during pathological assessment of neck dissections for non-thyroid cancers of the upper aero-digestive tract is critically reviewed. Special emphasis is given to controversies over normal-looking, nodal, thyroid follicles. Arguments for and against the benign nature of these follicles are considered together with processes that could be involved in their formation. The admittedly limited evidence suggests that benign, thyroid follicular inclusions rarely occur in cervical lymph nodes. Histological criteria that could be helpful in recognizing the inclusions, which include assessing their extent in conjunction with the size of the node, are discussed. Finally, an algorithm based on collaboration between specialists, correlating histological findings with imaging and loco-regional control of the upper aero-digestive tract cancer, is suggested for the management of patients with incidentally discovered, nodal thyroid tissue.

Indexed as

Incidental FindingsThyroid GlandAdultAlgorithmsCarcinoma, PapillaryChoristomaFemaleHumansLymphadenopathyLymphatic MetastasisLymph Node ExcisionLymph NodesMaleMiddle AgedNeckNeck DissectionHeterotopiaLymph nodesMetastasisNeck dissectionPathologyThyroid

Identifiers

PMID26459007
PMCPMC5525538
OpenAlexW1921441017

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.