ArticleJournal of molecular evolution2015
Are Synonymous Substitutions in Flowering Plant Mitochondria Neutral?
Article in Journal of molecular evolution, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
8 citing papers in PubMed, 22 citations in OpenAlex.
- Evolution and maintenance of mtDNA gene content across eukaryotes.The Biochemical journal · 2024Review
- Article
- Detecting de novo mitochondrial mutations in angiosperms with highly divergent evolutionary rates.Genetics · 2021Article
- Plant Mitochondria are a Riddle Wrapped in a Mystery Inside an Enigma.Journal of molecular evolution · 2021Article
- Article
- The Tempo and Mode of Angiosperm Mitochondrial Genome Divergence Inferred from Intraspecific Variation inG3 (Bethesda, Md.) · 2020Article
- Mitochondrial DNA Repair in anPlants (Basel, Switzerland) · 2020Article
- Disentangling the intertwined roles of mutation, selection and drift in the mitochondrial genome.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2020Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Angiosperm mitochondrial genes appear to have very low mutation rates, while non-gene regions expand, diverge, and rearrange quickly. One possible explanation for this disparity is that synonymous substitutions in plant mitochondrial genes are not truly neutral and selection keeps their occurrence low. If this were true, the explanation for the disparity in mutation rates in genes and non-genes needs to consider selection as well as mechanisms of DNA repair. Rps14 is co-transcribed with cob and rpl5 in most plant mitochondrial genomes, but in some genomes, rps14 has been duplicated to the nucleus leaving a pseudogene in the mitochondria. This provides an opportunity to compare neutral substitution rates in pseudogenes with synonymous substitution rates in the orthologs. Genes and pseudogenes of rps14 have been aligned among different species and the mutation rates have been calculated. Neutral substitution rates in pseudogenes and synonymous substitution rates in genes are significantly different, providing evidence that synonymous substitutions in plant mitochondrial genes are not completely neutral. The non-neutrality is not sufficient to completely explain the exceptionally low mutation rates in land plant mitochondrial genomes, but selective forces appear to play a small role.
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