ArticleEuropean journal of nutrition2017
Preventive rather than therapeutic treatment with high fiber diet attenuates clinical and inflammatory markers of acute and chronic DSS-induced colitis in mice.
Article in European journal of nutrition, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed, 71 citations in OpenAlex.
- Long-term regulatory effects of high-fiber low-fat diet on gut microbiota diversity and inflammatory marker expression in DSS-induced recurrent colitis in mice.Open medicine (Warsaw, Poland) · 2026Article
- A Short Dietary Screener Captures Food Items and Dietary Patterns That Associate With Inflammation in Inflammatory Bowel Disease.Crohn's & colitis 360 · 2025Article
- Associations of digestive diseases exposure and lifestyle factors with Parkinson's disease.NPJ Parkinson's disease · 2025Article
- Dietary content and eating behavior in ulcerative colitis: a narrative review and future perspective.Nutrition journal · 2025Review
- Dietary fibers boost gut microbiota-produced B vitamin pool and alter host immune landscape.Microbiome · 2024Article
- Lactic Acid Bacteria-Gut-Microbiota-Mediated Intervention towards Inflammatory Bowel Disease.Microorganisms · 2024Review
- The Severity of DSS-Induced Colitis Is Independent of the SCFA-FFAR2/3-GLP-1 Pathway Despite SCFAs Inducing GLP-1 Secretion via FFAR2/3.Metabolites · 2024Article
- Dietary fiber is a critical determinant of pathologic ILC2 responses and intestinal inflammation.The Journal of experimental medicine · 2024Article
- Nutritional regulation of microbiota-derived metabolites: Implications for immunity and inflammation.Immunity · 2024Review
- Nutrigenomic underpinnings of intestinal stem cells in inflammatory bowel disease and colorectal cancer development.Frontiers in genetics · 2024Review
- Article
- The Role of Dietary Fibre in Enteral Nutrition in Sepsis Prevention and Therapy: A Narrative Review.Nutrients · 2023Review
- Pretreatment withFrontiers in microbiology · 2023Article
- Curcumin-Loaded Microspheres Are Effective in Preventing Oxidative Stress and Intestinal Inflammatory Abnormalities in Experimental Ulcerative Colitis in Rats.Molecules (Basel, Switzerland) · 2022Article
- The effect of phenobarbital treatment on behavioral comorbidities and on the composition and function of the fecal microbiome in dogs with idiopathic epilepsy.Frontiers in veterinary science · 2022Article
- Current recommendations on the role of diet in the aetiology and management of IBD.Frontline gastroenterology · 2022Article
- Diet-Microbiota Interactions in Inflammatory Bowel Disease.Nutrients · 2021Review
- The Role of Diet in the Pathogenesis and Management of Inflammatory Bowel Disease: A Review.Nutrients · 2020Review
- EEN Yesterday and Today … CDED Today and Tomorrow.Nutrients · 2020Review
- The Role of Gut Microbiota Biomodulators on Mucosal Immunity and Intestinal Inflammation.Cells · 2020Review
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeInflammatory bowel diseases (IBDs) are chronic inflammatory disorders with important impact on global health. Prebiotic and probiotic strategies are thought to be useful in the context of experimental IBD. Here, we compared the effects of preventive versus therapeutic treatment with a high fiber diet (prebiotic) in combination or not with Bifidobacterium longum (probiotic) in a murine model of chronic colitis.
methodsColitis was induced by adding dextran sulfate sodium (DSS) to drinking water for 6 days (acute colitis) or for 5 cycles of DSS (chronic colitis).
resultsAdministration of the high fiber diet protected from acute colitis. Protection was optimal when diet was started 20 days prior to DSS. A 5-day pretreatment with acetate, a short-chain fatty acid, provided partial protection against acute colitis. In chronic colitis, pretreatment with the high fiber diet attenuated clinical and inflammatory parameters of disease. However, when the treatment with the high fiber diet started after disease had been established, overall protection was minimal. Similarly, delayed treatment with acetate or B. longum did not provide any protection even when the probiotic was associated with the high fiber diet.
conclusionPreventive use of a high fiber diet or acetate clearly protects mice against acute and chronic damage induced by DSS in mice. However, protection is lost when therapies are initiated after disease has been established. These results suggest that any therapy aimed at modifying the gut environment (e.g., prebiotic or probiotic strategies) should be given early in the course of disease.
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