ArticleParticle and fibre toxicology2015
Silica coating influences the corona and biokinetics of cerium oxide nanoparticles.
Article in Particle and fibre toxicology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 54 citations in OpenAlex.
- Development of a Collagen-Cerium Oxide Nanohydrogel for Wound Healing: In Vitro and In Vivo Evaluation.Biomedicines · 2025Article
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- Microfluidics-generated PLA nanoparticles: impact of purification method on macrophage interactions, anti-inflammatory effects, biodistribution, and protein corona formation.RSC pharmaceutics · 2025Article
- Ingested Polystyrene Nanospheres Translocate to Placenta and Fetal Tissues in Pregnant Rats: Potential Health Implications.Nanomaterials (Basel, Switzerland) · 2023Article
- An In Vitro Dosimetry Tool for the Numerical Transport Modeling of Engineered Nanomaterials Powered by the Enalos RiskGONE Cloud Platform.Nanomaterials (Basel, Switzerland) · 2022Article
- Silica encapsulation of ZnO nanoparticles reduces their toxicity for cumulus cell-oocyte-complex expansion.Particle and fibre toxicology · 2021Article
- Pulmonary fate and consequences of transferrin-functionalized gold nanoparticles.Nanotheranostics · 2021Article
- Isolation methods for particle protein corona complexes from protein-rich matrices.Nanoscale advances · 2020Review
- Physicochemical and Morphological Transformations of Chitosan Nanoparticles across the Gastrointestinal Tract and Cellular Toxicity in an In Vitro Model of the Small Intestinal Epithelium.Journal of agricultural and food chemistry · 2020Article
- Iron Oxide Nanoparticle-Induced Neoplastic-Like Cell TransformationChemical research in toxicology · 2019Article
- The impact of nanomaterial characteristics on inhalation toxicity.Toxicology research · 2018Review
- Article
- Preparation and Characterization of WS₂@SiO₂ and WS₂@PANI Core-Shell Nanocomposites.Nanomaterials (Basel, Switzerland) · 2018Article
- Physiologically based pharmacokinetic modeling of nanoceria systemic distribution in rats suggests dose- and route-dependent biokinetics.International journal of nanomedicine · 2018Article
- Protein corona: implications for nanoparticle interactions with pulmonary cells.Particle and fibre toxicology · 2017Article
- An integrated methodology for assessing the impact of food matrix and gastrointestinal effects on the biokinetics and cellular toxicity of ingested engineered nanomaterials.Particle and fibre toxicology · 2017Article
- Nanoparticle exposures from nano-enabled toner-based printing equipment and human health: state of science and future research needs.Critical reviews in toxicology · 2017Review
- Preparation, characterization, and in vitro dosimetry of dispersed, engineered nanomaterials.Nature protocols · 2017Article
- Surface modification of zinc oxide nanoparticles with amorphous silica alters their fate in the circulation.Nanotoxicology · 2016Article
- Article
Corrections and comments
- Erratum issued
Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundThe physicochemical properties of nanoparticles (NPs) influence their biological outcomes.
methodsWe assessed the effects of an amorphous silica coating on the pharmacokinetics and pulmonary effects of CeO2 NPs following intratracheal (IT) instillation, gavage and intravenous injection in rats. Uncoated and silica-coated CeO2 NPs were generated by flame spray pyrolysis and later neutron-activated. These radioactive NPs were IT-instilled, gavaged, or intravenously (IV) injected in rats. Animals were analyzed over 28 days post-IT, 7 days post-gavage and 2 days post-injection.
resultsOur data indicate that silica coating caused more but transient lung inflammation compared to uncoated CeO2. The transient inflammation of silica-coated CeO2 was accompanied by its enhanced clearance. Then, from 7 to 28 days, clearance was similar although significantly more (141)Ce from silica-coated (35%) was cleared than from uncoated (19%) (141)CeO2 in 28 days. The protein coronas of the two NPs were significantly different when they were incubated with alveolar lining fluid. Despite more rapid clearance from the lungs, the extrapulmonary (141)Ce from silica-coated (141)CeO2 was still minimal (<1%) although lower than from uncoated (141)CeO2 NPs. Post-gavage, nearly 100% of both NPs were excreted in the feces consistent with very low gut absorption. Both IV-injected (141)CeO2 NP types were primarily retained in the liver and spleen. The silica coating significantly altered the plasma protein corona composition and enhanced retention of (141)Ce in other organs except the liver.
conclusionWe conclude that silica coating of nanoceria alters the biodistribution of cerium likely due to modifications in protein corona formation after IT and IV administration.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.