Evidence map›Paper›PMID 26458943›Full record

ArticlePediatric rheumatology online journal2015

Effects of acute exercise on circulating endothelial and progenitor cells in children and adolescents with juvenile idiopathic arthritis and healthy controls: a pilot study.

Joyce Obeid, Thanh Nguyen, Tania Cellucci, Maggie J Larché, Brian W Timmons

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pediatric rheumatology online journal, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
0.6field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 14 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Joyce ObeidChild Health and Exercise Medicine Program, McMaster University, HSC 3N27G, 1280 Main Street West, Hamilton, L8S 4K1, ON, Canada. obeidj@mcmaster.ca.
Thanh NguyenChild Health and Exercise Medicine Program, McMaster University, HSC 3N27G, 1280 Main Street West, Hamilton, L8S 4K1, ON, Canada. nguyet54@mcmaster.ca.
Tania CellucciDepartment of Pediatrics, Division of Rheumatology, McMaster University, 1280 Main St W, Health Sciences Centre, Hamilton, L8S 4K1, ON, Canada. celluct@mcmaster.ca.
Maggie J LarchéDepartments of Medicine and Pediatrics, Division of Rheumatology, McMaster University, Hamilton, ON, Canada. mlarche@mcmaster.ca.
Brian W TimmonsChild Health and Exercise Medicine Program, McMaster University, HSC 3N27G, 1280 Main Street West, Hamilton, L8S 4K1, ON, Canada. timmonbw@mcmaster.ca.
McMaster University · CAHealth Sciences Centre · CA

Funding

Canadian Institutes of Health Research
6 · The paper itself

Abstract

backgroundYouth with juvenile idiopathic arthritis (JIA) may be at risk of poor cardiovascular health. Circulating endothelial progenitor cells (EPCs) and circulating endothelial cells (CECs) are markers of cardiovascular repair and damage, respectively, and respond to exercise. The objectives of this study were to compare resting levels of EPCs and CECs in JIA and controls, and to assess the effects of distinct types of exercise on EPCs and CECs in JIA and controls.

methodsSeven youth with JIA and six controls completed 3 visits. First, aerobic fitness was assessed. Participants then performed either moderate intensity, continuous exercise (MICE) or high intensity, intermittent exercise (HIIE) on separate days. Blood samples were collected at the beginning (REST), mid-point (MID) and end of exercise (POST) for determination of EPCs (CD31(+)CD34(bright)CD45(dim)CD133(+)) and CECs (CD31(bright)CD34(+)CD45(-)CD133(-)) by flow cytometry. Between group differences in EPCs and CECs were examined using two-way ANOVA, followed by Tukey's HSD post hoc, where appropriate. Statistical significance set at p ≤ 0.05.

resultsBoth EPCs and CECs were similar between groups at REST (p = 0.18-0.94). During MICE, EPCs remained unchanged in JIA (p = 0.95) but increased significantly at POST in controls (REST: 0.91 ± 0.55 × 10(6) cells/L vs. POST: 1.53 ± 0.36 × 10(6) cells/L, p = 0.04). Compared with controls, lower levels of EPCs were observed in JIA at MID (0.48 ± 0.50 × 10(6) cells/L vs. 1.10 ± 0.39 × 10(6) cells/L, p = 0.01) and POST (0.38 ± 0.34 × 10(6) cells/L vs. 1.53 ± 0.36 × 10(6) cells/L, p < 0.001) during MICE. No changes were detected in CECs with MICE in JIA and controls (p = 0.69). Neither EPCs nor CECs were modified with HIIE (p = 0.28-0.69).

conclusionYouth with JIA demonstrated a blunted EPC response to MICE when compared with controls. Future work should examine factors that may increase or normalize EPC mobilization in JIA.

Indexed as

AdolescentArthritis, JuvenileBiomarkersCase-Control StudiesChildEndothelial Progenitor CellsExerciseFemaleFlow CytometryHumansMalePilot ProjectsBiomarkers

Identifiers

PMID26458943
PMCPMC4604015
OpenAlexW1900247493

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.