ArticleCancer causes & control : CCC2016
Comparing SurePath, ThinPrep, and conventional cytology as primary test method: SurePath is associated with increased CIN II+ detection rates.
Article in Cancer causes & control : CCC, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07211204 (Study To Compare The Efficacy Of Cervical Cytology With Molecular Screening In The Detection Of Reactive Cellular Changes In The Cervix In An Open Population), which is not on this map. Cited by 21 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Study To Compare The Efficacy Of Cervical Cytology With Molecular Screening In The Detection Of Reactive Cellular Changes In The Cervix In An Open Population
Who cites it
21 citing papers in PubMed.
- Effect of brush rinse on the diagnostic accuracy of biliary stricture evaluation: A multicenter trial.World journal of clinical cases · 2025Article
- Advancements in the Management of Cervical Intraepithelial Neoplasia: A Comprehensive Review.Cureus · 2024Review
- Optimal Screening and Detection Strategies for Cervical Lesions: A Retrospective Study.Journal of Cancer · 2024Article
- The Efficiency of Cervical Pap and Comparison of Conventional Pap Smear and Liquid-Based Cytology: A Review.Cureus · 2023Review
- Clinical characteristics and a 2-year follow-up of unsatisfactory conventional Pap smears: a retrospective case-control study.Scientific reports · 2022Article
- A Comparative Analysis of Deep Learning Models for Automated Cross-Preparation Diagnosis of Multi-Cell Liquid Pap Smear Images.Diagnostics (Basel, Switzerland) · 2022Article
- Diagnostic Management of Oncogenic HPV Cervical Infections: The Field Experience in Wuxi, China.Frontiers in medicine · 2022Article
- Repeated Positive Cervical HPV Testing and Absent or Minor Cytology Abnormality at Pap Smear. What is the Next Step?Asian Pacific journal of cancer prevention : APJCP · 2021Article
- Comparison of smear cytology with liquid-based cytology in pancreatic lesions: A systematic review and meta-analysis.World journal of clinical cases · 2021Article
- High-grade cervical lesions after vaccination against human papillomavirus: A Danish cohort study.Acta obstetricia et gynecologica Scandinavica · 2020Article
- Cost-Effectiveness and Cost-Benefit of Cervical Cancer Screening with Liquid Based Cytology Compared with Conventional Cytology in Germany.ClinicoEconomics and outcomes research : CEOR · 2020Article
- HPV genotyping and p16/Ki-67 test significantly improve detection rate of high-grade cervical squamous intraepithelial lesion.Archives of medical science : AMS · 2020Article
- Comparison of the Diagnostic Utility of Manual Screening and the ThinPrep Imaging System in Liquid-Based Cervical Cytology.Turk patoloji dergisi · 2020Article
- Bayesian analysis of baseline risk of CIN2 and ≥CIN3 by HPV genotype in a European referral cohort.International journal of cancer · 2019Article
- Liquid-based cytopathology test as a novel method to identify Aspergillus in patients with pulmonary aspergillosis.Scientific reports · 2017Article
- Harms of cervical cancer screening in the United States and the Netherlands.International journal of cancer · 2017Article
- Cervical cancer incidence after normal cytological sample in routine screening using SurePath, ThinPrep, and conventional cytology: population based study.BMJ (Clinical research ed.) · 2017Article
- Can an inadequate cervical cytology sample in ThinPrep be converted to a satisfactory sample by processing it with a SurePath preparation?CytoJournal · 2017Article
- The BD Onclarity HPV Assay on Samples Collected in SurePath Medium Meets the International Guidelines for Human Papillomavirus Test Requirements for Cervical Screening.Journal of clinical microbiology · 2016Article
- Comparative Analysis of Conventional Cytology and Liquid-Based Cytology in the Detection of Carcinoma Cervix and its Precursor Lesions.Journal of cytologyArticle
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeWithin the last decade, SurePath and ThinPrep [both liquid-based cytology (LBC) tests] have replaced conventional cytology (CC) as primary test method in cervical cancer screening programs of multiple countries. The aim of our study was to examine the effect in the Dutch screening program.
methodsAll primary smears taken within this program from 2000 to 2011 were analyzed using the nationwide registry of histo- and cytopathology (PALGA) with a follow-up until March 2013. The percentage of smears classified as borderline/mildly dyskaryotic (BMD) and >BMD as well as CIN and cervical cancer detection rates were compared between SurePath and ThinPrep versus CC by logistic regression analyses (adjusted for age, screen region, socioeconomic status, and calendar time).
resultsWe included 3,118,685 CC, 1,313,731 SurePath, and 1,584,587 ThinPrep smears. Using SurePath resulted in an increased rate of primary smears classified as >BMD [odds ratio (OR) = 1.12 (95% confidence interval (CI) 1.09-1.16)]. CIN I and II(+) detection rates increased by 14 % [OR = 1.14 (95% CI 1.08-1.20)] and 8 % [OR = 1.08 (95% CI 1.05-1.12)]. Cervical cancer detection rates were unaffected. Implementing ThinPrep did not result in major alterations of the cytological classification of smears, and it did not affect CIN detection rates. While not significant, cervical cancer detection rates were lower [OR = 0.87 (95% CI 0.75-1.01)].
conclusionsThe impact of replacing CC by LBC as primary test method depends on the type of LBC test used. Only the use of SurePath was associated with increased CIN II(+) detection, although it simultaneously increased the detection of CIN I.
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