Trial reportBMC oral health2015
Small-diameter titanium grade IV and titanium-zirconium implants in edentulous mandibles: five-year results from a double-blind, randomized controlled trial.
Trial report in BMC oral health, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01878331 (Long-term, Prospective, Cohort Study to Evaluate Safety and Efficacy of Two Different Dental Implant Alloys in Straumann 3.3mm Diameter Bone Level Implants for Removable Prosthesis in Patients With Edentulous Mandibles), which is not on this map. Cited by 24 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Long-term, Prospective, Cohort Study to Evaluate Safety and Efficacy of Two Different Dental Implant Alloys in Straumann 3.3mm Diameter Bone Level Implants for Removable Prosthesis in Patients With Edentulous Mandibles
Who cites it
24 citing papers in PubMed, 2 syntheses or guidelines pooled it, 74 citations in OpenAlex.
- Clinical effectiveness of Zirconia versus titanium dental implants in anterior region: an overview of systematic reviews.European journal of medical research · 2025Pooled it
- Use of Narrow-Diameter Implants in Completely Edentulous Patients as a Prosthetic Option: A Systematic Review of the Literature.BioMed research international · 2021Pooled it
- Clinical and Radiographic Performance of Two Distinct Sandblasted, Large-Grit, Acid-Etched Implant Surfaces: A Split-Mouth Randomized Clinical Trial.Clinical oral implants research · 2026Trial
- Immediate versus conventional loading in users of mandibular overdentures retained by narrow-diameter implants: results from a 5-year randomized clinical trial.Clinical oral investigations · 2026Trial
- Mandibular overdentures retained by 1 or 2 implants: a 5-year randomized clinical trial on implant stability and peri-implant outcomes.Clinical oral investigations · 2024Trial
- Immunohistochemical Evaluation of Peri-Implant Soft Tissues around Machined and Direct Metal Laser Sintered (DMLS) Healing Abutments in Humans.International journal of environmental research and public health · 2018Trial
- Implant Surface Characteristics and Peri-Implant Outcomes: A Systematic Review of Clinical and Microbiological Evidence.Bioengineering (Basel, Switzerland) · 2026Review
- Functional, Patient-Centered and Bone Remodeling Outcomes in Two Narrow-Diameter Implant Retained Mandibular Overdenture Wearers After 5 Years of Follow-Up: A Prospective Case Series.Clinical oral implants research · 2025Article
- The impact of physiological and parafunctional posterior occlusal forces on experimental Ti-15Zrsupracrestal dental implant - a finite element analysis.Medicine and pharmacy reports · 2025Article
- Influence of Cyclic Loading on the Removal Torque of Unique Subperiosteal Implant Screws.Journal of functional biomaterials · 2025Article
- Comparative Clinical Behavior of Zirconia versus Titanium Dental Implants: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.Journal of clinical medicine · 2024Review
- A Microscopy Evaluation of Emergence Profile Surfaces of Dental Custom CAD-CAM Implant Abutments and Dental Implant Stock Abutments.Journal of personalized medicine · 2024Article
- Bone marrow stromal cells generate an osteoinductive microenvironment when cultured on titanium-aluminum-vanadium substrates with biomimetic multiscale surface roughness.Biomedical materials (Bristol, England) · 2023Article
- Functional engineering strategies of 3D printed implants for hard tissue replacement.Regenerative biomaterials · 2023Review
- Custom-Made Direct Metal Laser Sintering Titanium Subperiosteal Implants in Oral and Maxillofacial Surgery for Severe Bone-Deficient Patients-A Pilot Study.Diagnostics (Basel, Switzerland) · 2022Article
- Periodontitis and peri-implantitis in elderly people experiencing institutional and hospital confinement.Periodontology 2000 · 2022Review
- Clinical Performance Comparing Titanium and Titanium-Zirconium or Zirconia Dental Implants: A Systematic Review of Randomized Controlled Trials.Dentistry journal · 2022Review
- Endosseous Dental Implant Materials and Clinical Outcomes of Different Alloys: A Systematic Review.Materials (Basel, Switzerland) · 2022Review
- A fixed reconstruction of fully edentulous patients with immediate function using an apically tapered implant design: a retrospective clinical study.International journal of implant dentistry · 2020Article
- Descriptive retrospective study analyzing relevant factors related to dental implant failure.Medicina oral, patologia oral y cirugia bucal · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 5 institutions in 5 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe aim of this study was to compare the 5-year survival and success rates of 3.3 mm dental implants either made from titanium-zirconium (TiZr) alloy or from Grade IV titanium (Ti Grade IV) in mandibular implant-based removable overdentures.
methodsThe core study had a follow-up period of 36 months and was designed as a randomized, controlled, double-blind, split-mouth multicenter clinical trial. Patients with edentulous mandibles received two Straumann Bone Level implants (diameter 3.3 mm, SLActive®), one of TiZr (test) and one of Ti Grade IV (control), in the interforaminal region. This follow-up study recruited patients from the core study and evaluated the plaque and sulcus bleeding indices, radiographic crestal bone level, as well as implant survival and success 60 months after implant placement.
resultsOf the 91 patients who initially received implants, 75 completed the 36 month follow-up and 49 were available for the 60 month examination. Two patients were excluded so that a total of 47 patients with an average age of 72 ± 8 years were analysed. The characteristics and 36-month performance of the present study cohort did not differ from the non-included initial participants (p > 0.05). In the period since the 36-month follow-up examination, no implant was lost. The cumulative implant survival rate was 98.9 % for the TiZr group and 97.8 % for the Ti Grade IV group. Crestal bone level changes at 60 months were not different in the test and control group (TiZr -0.60 ± 0.69 mm and Ti Grade IV -0.61 ± 0.83 mm; p = 0.96). The cumulative implant success rate after 60 months was 95.8 and 92.6 % for TiZr and Ti Grade IV, respectively.
conclusionsAfter 60 months, the positive outcomes of the 36 month results for TiZr and Ti Grade IV implants were confirmed, with no significant differences with regard to crestal bone level change, clinical parameters and survival or success rates. TiZr implants performed equally well compared to conventional Ti Grade IV 3.3 mm diameter-reduced implants for mandibular removable overdentures.
trial registrationRegistered on www.clinicaltrials.gov: NCT01878331.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.