ReviewNature reviews. Urology2015
The practical management of testosterone deficiency in men.
Review in Nature reviews. Urology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 74 citations in OpenAlex.
- Testosterone status and bone mineral density in Finnish male endurance athletes: Baseline associations and 1-year follow-up.Physiological reports · 2026Article
- Genetic Testing for Monogenic Forms of Male Infertility Contributes to the Clinical Diagnosis of Men with Severe Idiopathic Male Infertility.The world journal of men's health · 2025Article
- The effect of transient sex hormone fluctuations on vascular endothelial function.American journal of physiology. Heart and circulatory physiology · 2025Review
- Dynamics of serum testosterone and biological aging in men: insights from Chinese, American, and British populations.EClinicalMedicine · 2025Article
- Association between uric acid/high-density lipoprotein cholesterol ratio and testosterone deficiency in adult American men: findings from the national health and nutrition examination survey 2011-2016.BMC public health · 2025Article
- Mechanism of salidroside promoting testosterone secretion induced by HFrontiers in chemistry · 2025Article
- Association between weight-adjusted waist index and testosterone deficiency in adult American men: findings from the national health and nutrition examination survey 2013-2016.BMC public health · 2024Article
- Article
- Association between life's essential 8 and male biochemical androgen deficiency: evidence from NHANES 2013-2016.Frontiers in endocrinology · 2024Article
- Association between life's essential 8 and testosterone deficiency in US men: findings from national health and nutrition examination survey (NHANES) 2011-2016.Frontiers in endocrinology · 2024Article
- Association of geriatric nutritional risk index with total testosterone in elderly adults in the US: evidence from NHANES 2011-2016.Frontiers in endocrinology · 2024Article
- Comparison of Intratesticular Testosterone between Men Receiving Nasal, Intramuscular, and Subcutaneous Pellet Testosterone Therapy: Evaluation of Data from Two Single-Center Randomized Clinical Trials.The world journal of men's health · 2023Article
- Update on canine anorchia: A review.Veterinary medicine and science · 2023Review
- The association between sex hormones and periodontitis among American adults: A cross-sectional study.Frontiers in endocrinology · 2023Article
- Article
- Increased risk of testosterone deficiency is associated with the systemic immune-inflammation index: a population-based cohort study.Frontiers in endocrinology · 2022Article
- Article
- Hypogonadism in Exercising Males: Dysfunction or Adaptive-Regulatory Adjustment?Frontiers in endocrinology · 2020Review
- Testosterone Supplementation and Cognitive Functioning in Men-A Systematic Review and Meta-Analysis.Journal of the Endocrine Society · 2019Article
- Testosterone in renal transplant patients: effect on body composition and clinical parameters.Journal of nephrology · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Despite increased global interest in testosterone deficiency in men and its treatment with testosterone therapy, practical aspects of care remain confusing to many practitioners. Testosterone deficiency can result from testicular dysfunction (primary hypogonadism) or hypothalamic-pituitary dysfunction (secondary hypogonadism), and be congenital or acquired. Sexual and nonsexual symptoms of testosterone deficiency can negatively affect quality of life and cause considerable general health concerns. Investigation of testosterone deficiency should be undertaken in men with symptoms of reduced libido, erectile dysfunction, depression, fatigue, poor concentration, and poor memory. Total and free testosterone are the most frequently used tests and evaluating serum concentrations of luteinizing hormone aids determination of primary versus secondary testosterone deficiency. Multiple formulations of testosterone therapy are available, but symptomatic benefits might not manifest for several weeks to many months; long-acting formulations are convenient and improve compliance. Concerns regarding cardiovascular and prostate cancer risks are not supported by current evidence, monitoring during therapy is mandatory. On balance, testosterone therapy can be considered a safe and effective treatment for testosterone deficiency.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.