Evidence map›Paper›PMID 26458541›Full record

ArticleBMC nephrology2015

Nephrology co-management versus primary care solo management for early chronic kidney disease: a retrospective cross-sectional analysis.

Lipika Samal, Adam Wright, Sushrut S Waikar, Jeffrey A Linder

Open access · goldAbstract readComparative Study
In one paragraph

Article in BMC nephrology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed, 2 pooled it
1.8field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 2 syntheses or guidelines pooled it, 47 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Electronic Decision Support for Management of CKD in Primary Care: A Pragmatic Randomized Trial.American journal of kidney diseases : the official journal of the National Kidney Foundation · 2020
    Trial
  4. A Microsimulation-Based Approach for Mitigating Societal Bias in Chronic Kidney Disease Data.Medical decision making : an international journal of the Society for Medical Decision Making · 2026
    Article
  5. Care Processes and Clinical Responses to Newly Detected Albuminuria: The Stockholm Creatinine Measurements (SCREAM) Project.American journal of kidney diseases : the official journal of the National Kidney Foundation · 2026
    Article
  6. Article
  7. A microsimulation-based framework for mitigating societal bias in primary care data.medRxiv : the preprint server for health sciences · 2025
    Article
  8. Article
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  13. Review
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  18. Article
  19. Importance of Early Screening and Diagnosis of Chronic Kidney Disease in Patients with Type 2 Diabetes.Diabetes therapy : research, treatment and education of diabetes and related disorders · 2021
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Lipika SamalDivision of General Medicine and Primary Care, Brigham and Women's Hospital, 1620 Tremont St., Boston, MA, 02120-1613, USA. lsamal@partners.org.
Adam WrightDivision of General Medicine and Primary Care, Brigham and Women's Hospital, 1620 Tremont St., Boston, MA, 02120-1613, USA. awright@partners.org.
Sushrut S WaikarHarvard Medical School, Boston, MA, 02120, USA. swaikar@partners.org.
Jeffrey A LinderDivision of General Medicine and Primary Care, Brigham and Women's Hospital, 1620 Tremont St., Boston, MA, 02120-1613, USA. jlinder@partners.org.
Brigham and Women's Hospital · US

Funding

Health Information Technology for Chronic Kidney Disease ManagementK23DK097187 · NIDDK · BRIGHAM AND WOMEN'S HOSPITAL · PI SAMAL, LIPIKA · 2013 to 2017
$920k
NIDDK NIH HHS K23 DK097187NIDDK NIH HHS K23DK097187
6 · The paper itself

Abstract

backgroundPrimary care physicians (PCPs) typically manage early chronic kidney disease (CKD), but recent guidelines recommend nephrology co-management for some patients with stage 3 CKD and all patients with stage 4 CKD. We sought to compare quality of care for co-managed patients to solo managed patients.

methodsWe conducted a retrospective cross-sectional analysis. Patients included in the study were adults who visited a PCP during 2009 with laboratory evidence of CKD in the preceding two years, defined as two estimated glomerular filtration rates (eGFR) between 15-59 mL/min/1.73 m(2) separated by 90 days. We assessed process measures (serum eGFR test, urine protein/albumin test, angiotensin converting enzyme inhibitor or angiotensin receptor blocker [ACE/ARB] prescription, and several tests monitoring for complications) and intermediate clinical outcomes (mean blood pressure and blood pressure control) and performed subgroup analyses by CKD stage.

resultsOf 3118 patients, 11 % were co-managed by a nephrologist. Co-management was associated with younger age (69 vs. 74 years), male gender (46 % vs. 34 %), minority race/ethnicity (black 32 % vs. 22 %; Hispanic 13 % vs. 8 %), hypertension (75 % vs. 66 %), diabetes (42 % vs. 26 %), and more PCP visits (5.0 vs. 3.9; p < 0.001 for all comparisons). After adjustment, co-management was associated with serum eGFR test (98 % vs. 94 %, p = <0.0001), urine protein/albumin test (82 % vs 36 %, p < 0.0001), and ACE/ARB prescription (77 % vs. 69 %, p = 0.03). Co-management was associated with monitoring for anemia and metabolic bone disease, but was not associated with lipid monitoring, differences in mean blood pressure (133/69 mmHg vs. 131/70 mmHg, p > 0.50) or blood pressure control. A subgroup analysis of Stage 4 CKD patients did not show a significant association between co-management and ACE/ARB prescription (80 % vs. 73 %, p = 0.26).

conclusionFor stage 3 and 4 CKD patients, nephrology co-management was associated with increased stage-appropriate monitoring and ACE/ARB prescribing, but not improved blood pressure control.

Indexed as

AgedAged, 80 and overAge FactorsAngiotensin-Converting Enzyme InhibitorsAngiotensin Receptor AntagonistsBlack or African AmericanComorbidityCross-Sectional StudiesDiabetes MellitusDrug PrescriptionsFemaleGlomerular Filtration RateHispanic or LatinoHumansHypertensionKidney Function TestsAngiotensin-Converting Enzyme InhibitorsAngiotensin Receptor Antagonists

Identifiers

PMID26458541
PMCPMC4603818
OpenAlexW2130313746

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.