ReviewCurrent genetics2016
Bacterial differentiation via gradual activation of global regulators.
Review in Current genetics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed.
- A metabolite morphogen coordinates multicellular development inScience advances · 2026Article
- Article
- MOB rules: Antibiotic Exposure Reprograms Metabolism to MobilizebioRxiv : the preprint server for biology · 2024Article
- Regulating Pathways ofInternational journal of molecular sciences · 2023Article
- Review
- Structure-seq2 probing of RNA structure upon amino acid starvation reveals both known and novel RNA switches inRNA (New York, N.Y.) · 2020Article
- Tetanus Toxin Synthesis is Under the Control of A Complex Network of Regulatory Genes inToxins · 2020Article
- The Stress-Responsive Alternative Sigma Factor SigB ofFrontiers in microbiology · 2020Review
- The Plant Host Induces Antibiotic Production To Select the Most-Beneficial Colonizers.Applied and environmental microbiology · 2019Article
- Transcription factor network efficiency in the regulation of Candida albicans biofilms: it is a small world.Current genetics · 2018Article
- Transcription termination factor Rho and microbial phenotypic heterogeneity.Current genetics · 2018Review
- Chromosomal organization of transcription: in a nutshell.Current genetics · 2018Review
- Collective Vortex-Like Movement ofFrontiers in microbiology · 2018Article
- The PAS domains of the major sporulation kinase in Bacillus subtilis play a role in tetramer formation that is essential for the autokinase activity.MicrobiologyOpen · 2017Article
- Termination factor Rho: From the control of pervasive transcription to cell fate determination in Bacillus subtilis.PLoS genetics · 2017Article
- Presence of Calcium Lowers the Expansion of Bacillus subtilis Colony Biofilms.Microorganisms · 2017Article
- The cell envelope stress response of Bacillus subtilis: from static signaling devices to dynamic regulatory network.Current genetics · 2017Review
- Lack of formylated methionyl-tRNA has pleiotropic effects on Bacillus subtilis.Microbiology (Reading, England) · 2017Article
- The Rcs regulon in Proteus mirabilis: implications for motility, biofilm formation, and virulence.Current genetics · 2016Article
- Monitoring Spatial Segregation in Surface Colonizing Microbial Populations.Journal of visualized experiments : JoVE · 2016Article
Corrections and comments
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Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bacteria have evolved to adapt to various conditions and respond to certain stress conditions. The ability to sense and efficiently reply to these environmental effects involve versatile array of sensors and global or specific regulators. Interestingly, modulation of the levels of active global regulators enables bacteria to respond to diverse signals via a single central transcriptional regulator and to activate or repress certain differentiation pathways at a spatio-temporal manner. The Gram-positive Bacillus subtilis is an ideal bacterium to study how membrane bound and cytoplasmic sensor kinases affect the level of phosphorylated global regulator, Spo0A which in response activates genes related to sliding, biofilm formation, and sporulation. In addition, other global regulators, including the two-component system DegS-DegU, modulate overlapping and complementary genes in B. subtilis related to surface colonization and biofilm formation. The intertwinement of global regulatory systems also allows the accurate modulation of differentiation pathways. Studies in the last decade enable us to get a deeper insight into the role of global regulators on the smooth transition of developmental processes in B. subtilis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.