ArticleThe Indian journal of medical research2015
Molecular characterization of community- & hospital-acquired methicillin-resistant & methicillin-sensitive Staphylococcus aureus isolates in Sikkim.
Article in The Indian journal of medical research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Phylogenomic associations among methicillin-resistantMicrobiology spectrum · 2025Article
- Molecular Characteristics of Community-Acquired Methicillin-ResistantIndian journal of microbiology · 2024Article
- Spectrum of Virulence Factors in Clinical Isolates ofJournal of laboratory physicians · 2023Article
- Prevalence of Methicillin-resistantOman medical journal · 2022Review
- Investigating the relation between resistance pattern and type of Staphylococcal cassette chromosomeIranian journal of microbiology · 2022Article
- High frequency of SCCIranian journal of microbiology · 2022Article
- Diversity of clonal complex 22 methicillin-resistantFrontiers in microbiology · 2022Article
- Prevalence and Characterization of Methicillin-ResistantAntibiotics (Basel, Switzerland) · 2021Article
- Article
- Antibiotic Susceptibility, Virulence Pattern, and Typing ofFrontiers in microbiology · 2019Article
- SCC mec typing and antimicrobial resistance of methicillin-resistant Staphylococcus aureus (MRSA) from pigs of Northeast India.Veterinary research communications · 2016Article
- Genotyping of Methicillin Resistant Staphylococcus aureus from Tertiary Care Hospitals in Coimbatore, South India.Journal of global infectious diseasesArticle
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4 authors.
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Abstract
BACKGROUND &
objectivesThe two major genotypic markers that distinguish community acquired (CA) from hospital acquired (HA) methicillin resistant Staphylococcus aureus (MRSA) isolates are the architecture of mobile genetic element (SCCmec type) and presence of panton valentine leukocidin (PVL) toxin. This study was conducted to determine the molecular characteristics of CA- and HA- MRSA and methicillin sensitive S. aureus (MSSA) isolates in Sikkim.
methodsA total of 150 clinical isolates of S. aureus isolated from various clinical specimens were subjected to duplex (mec-A and pvl gene) and multiplex (SCCmec typing) PCR.
resultsOf the 150 isolates, 53 (35.33%) and 66 (44%) were positive for mec-A (MRSA) and pvl genes, respectively. Thirty eight (25.33%) met the definition of CA-MRSA and 15 (10%) of HA-MRSA and the remaining 63 (42%) and 34 (22.66%) as CA- and HA-MSSA, respectively. No significant difference was seen in the distribution of PVL toxin in MRSA and MSSA isolates, but it was significantly (P<0.001) high in overall MRSA isolates than in MSSA. The majority of the MRSA isolates showed a double amplification band of SCCmec type III plus V (54.71%), and only a fewer isolates were amplified by single DNA fragments of type I (1.88%), III (3.77%), IVa (1.88%) and V (11.32%). SCCmec types I, III, IVa, were found only in HA-MRSA isolates, whereas type V in both the CA- and HA-MRSA. AST pattern showed that 18.42 per cent (7/38) and 46.66 per cent (7/15) were multidrug resistant (MDR)-CA-MRSA and MDR-HA-MRSA, respectively. INTERPRETATION &
conclusionsThe present results show that SCCmec type V MRSA has been on the rise, and genotypic markers such as pvl gene detection used for the differentiation of these clinically distinct isolates of MRSA may not be reliable.
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