ArticleThe Indian journal of medical research2015
Pneumococcal serotypes associated with invasive disease in under five children in India & implications for vaccine policy.
Article in The Indian journal of medical research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 2 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Cell wall-inhibiting antibiotics resistance in Streptococcus pneumoniae causing invasive diseases: a global systematic review and meta-analysis in pediatric populations.Italian journal of pediatrics · 2025Pooled it
- Global trends in macrolide and lincosamide resistance in Streptococcus species: a comprehensive systematic review and meta-analysis.BMC infectious diseases · 2025Pooled it
- Burden of bacterial meningitis in India: Preliminary data from a hospital based sentinel surveillance network.PloS one · 2018Trial
- Clinical and evidence-based considerations for choosing a pneumococcal conjugate vaccine in India: A narrative review.Human vaccines & immunotherapeutics · 2025Review
- Review
- Molecular detection and serotyping of acute bacterial meningitis pathogens in Indian children.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2025Article
- Update on the evolving landscape of pneumococcal capsule types: new discoveries and way forward.Clinical microbiology reviews · 2025Review
- Pneumococcal serotype prevalence and antibiotic resistance in children in South and Southeast Asia, 2012-2024.Human vaccines & immunotherapeutics · 2024Review
- Childhood Pneumonia: What's Unchanged, and What's New?Indian journal of pediatrics · 2023Review
- Serotype Distribution and Multi Locus Sequence Type (MLST) of Erythromycin-ResistantReports of biochemistry & molecular biology · 2023Article
- Epidemiology and outcomes of pneumococcal sepsis in children with nephrotic syndrome in a developing country.Pediatric nephrology (Berlin, Germany) · 2023Article
- Article
- Comparative genomics of invasive Streptococcus pneumoniae CC320/271 serotype 19F/19A before the introduction of pneumococcal vaccine in India.Molecular biology reports · 2021Article
- Article
- Observational
- Nasopharyngeal carriage of Streptococcus pneumoniae serotypes among children in India prior to the introduction of pneumococcal conjugate vaccines: a cross-sectional study.BMC infectious diseases · 2019Article
- Pneumococcal Vaccines - How Many Serotypes are Enough?Indian journal of pediatrics · 2018Review
- Article
- The current status of community-acquired pneumonia management and prevention in children under 5 years of age in India: a review.Therapeutic advances in infectious disease · 2016Review
- Molecular epidemiology of pneumococcal isolates from children in China.Saudi medical journal · 2016Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND &
objectivesStreptococcus pneumoniae is a major cause of morbidity and mortality especially in children less than five years, particularly in India. We present data on S.pneumoniae infections in children less than five years age group, with response to its serotype distribution, antibiotic resistance profile and available vaccines expected coverage.
methodsChildren aged less than five, who were suspected for invasive pneumococcal disease were included in the study and their sterile body fluids were investigated for the presence of S. pneumoniae. Invasive S. pneumoniae isolates from sterile body fluids were identified by bile solubility and optochin susceptibility test. Pneumococcal serotyping was performed with co-agglutination technique and reconfirmed with multiplex PCR.
resultsThe most common pneumococcal serotypes causing invasive infections in children less than five years of age were 14, 19F, 5, 6A and 6B. Of the 114 S. pneumoniae isolates studied, 110 (96.4%) were non-susceptible to co-trimoxazole and 30 per cent were non-susceptible to erythromycin, 5.2 per cent of the isolates were non-susceptible to penicillin and only 0.8 per cent was non-susceptible to cefotaxime. INTERPRETATION &
conclusionsOur results indicate that PCV-10 can protect against 64 per cent of serotypes causing invasive pneumococcal infections. Use of PCV-13 in this region can provide increase in protection upto 74.6 per cent against serotypes causing invasive pneumococcal infections. Incorporating PCV-13 in the Universal Immunization Programme may provide incremental protection against IPD serotypes in the southern region of the country.
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Registered trials
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