ArticlePLoS computational biology2015
Feed-Forward versus Feedback Inhibition in a Basic Olfactory Circuit.
Article in PLoS computational biology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 46 citations in OpenAlex.
- Article
- Overexpression of the schizophrenia risk gene C4 in PV cells drives sex-dependent behavioral deficits and circuit dysfunction.iScience · 2024Article
- Neuronal functional connectivity is impaired in a layer dependent manner near chronically implanted intracortical microelectrodes in C57BL6 wildtype mice.Journal of neural engineering · 2024Article
- Overexpression of the schizophrenia risk gene C4 in PV cells drives sex-dependent behavioral deficits and circuit dysfunction.bioRxiv : the preprint server for biology · 2024Article
- Investigating visual navigation using spiking neural network models of the insect mushroom bodies.Frontiers in physiology · 2024Article
- The functional logic of odor information processing in the Drosophila antennal lobe.PLoS computational biology · 2023Article
- Olfactory receptor neurons generate multiple response motifs, increasing coding space dimensionality.eLife · 2023Article
- The Anterior Piriform Cortex and Predator Odor Responses: Modulation by Inhibitory Circuits.Frontiers in behavioral neuroscience · 2022Review
- The Neurometabolic Basis of Mood Instability: The Parvalbumin Interneuron Link-A Systematic Review and Meta-Analysis.Frontiers in pharmacology · 2021Review
- Article
- Optimality of sparse olfactory representations is not affected by network plasticity.PLoS computational biology · 2020Article
- Regulation of gamma-frequency oscillation by feedforward inhibition: A computational modeling study.Hippocampus · 2019Article
- Adaptive integrate-and-fire model reproduces the dynamics of olfactory receptor neuron responses in a moth.Journal of the Royal Society, Interface · 2019Article
- Large time step discrete-time modeling of sharp wave activity in hippocampal area CA3.Communications in nonlinear science & numerical simulation · 2019Article
- Review
- Differential effects of adaptation on odor discrimination.Journal of neurophysiology · 2018Article
- Article
- Control of Absence Seizures by the Thalamic Feed-Forward Inhibition.Frontiers in computational neuroscience · 2017Article
- Dynamic balance of excitation and inhibition rapidly modulates spike probability and precision in feed-forward hippocampal circuits.Journal of neurophysiology · 2016Article
- Central processing in the mushroom bodies.Current opinion in insect science · 2014Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
Abstract
Inhibitory interneurons play critical roles in shaping the firing patterns of principal neurons in many brain systems. Despite difference in the anatomy or functions of neuronal circuits containing inhibition, two basic motifs repeatedly emerge: feed-forward and feedback. In the locust, it was proposed that a subset of lateral horn interneurons (LHNs), provide feed-forward inhibition onto Kenyon cells (KCs) to maintain their sparse firing--a property critical for olfactory learning and memory. But recently it was established that a single inhibitory cell, the giant GABAergic neuron (GGN), is the main and perhaps sole source of inhibition in the mushroom body, and that inhibition from this cell is mediated by a feedback (FB) loop including KCs and the GGN. To clarify basic differences in the effects of feedback vs. feed-forward inhibition in circuit dynamics we here use a model of the locust olfactory system. We found both inhibitory motifs were able to maintain sparse KCs responses and provide optimal odor discrimination. However, we further found that only FB inhibition could create a phase response consistent with data recorded in vivo. These findings describe general rules for feed-forward versus feedback inhibition and suggest GGN is potentially capable of providing the primary source of inhibition to the KCs. A better understanding of how inhibitory motifs impact post-synaptic neuronal activity could be used to reveal unknown inhibitory structures within biological networks.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.