Evidence map›Paper›PMID 26457599›Full record

ArticleTransplantation2016

Outcomes of Live Kidney Donors Who Develop End-Stage Renal Disease.

Abimereki D Muzaale, Allan B Massie, Lauren M Kucirka, Xun Luo, Komal Kumar, Ryan S Brown, Saad Anjum, Robert A Montgomery, Krista L Lentine, Dorry L Segev

Abstract read
In one paragraph

Article in Transplantation, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
5.0field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.

  1. Guideline
  2. Article
  3. The landscape of international living kidney donation in the United States.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2019
    Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. The National Landscape of Living Kidney Donor Follow-Up in the United States.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2017
    Article
  10. Review
  11. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Abimereki D Muzaale1 Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD. 2 Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD. 3 Division of Nephrology, Saint Louis University School of Medicine, St. Louis, MO. 4 Center for Outcomes Research, Saint Louis University School of Medicine, St. Louis, MO.
Allan B Massie
Lauren M Kucirka
Xun Luo
Komal Kumar
Ryan S Brown
Saad Anjum
Robert A Montgomery
Krista L Lentine
Dorry L Segev
Johns Hopkins University · US

Funding

MEDICAL SCIENTIST TRAINING PROGRAMT32GM007309 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI COX, ANDREA L · 1985 to 2019
$43.2M
Long-Term Health Outcomes After Live Kidney Donation in African AmericansR01DK096008 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI SEGEV, DORRY L. · 2013 to 2017
$3.8M
Patient Oriented Research in Kidney Disease and Transplant SurgeryK24DK101828 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI SEGEV, DORRY L. · 2014 to 2018
$922k
Understanding Mechanisms for Racial Disparities in Survival on DialysisF30DK095545 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI KUCIRKA, LAUREN MARIE · 2012 to 2016
$239k
NIDDK NIH HHS F30 DK095545NIDDK NIH HHS K24 DK101828NIDDK NIH HHS R01 DK096008NIGMS NIH HHS T32 GM007309
6 · The paper itself

Abstract

backgroundKidney donors can develop end-stage renal disease (ESRD) after donation, but the outcomes of those who do remain poorly characterized.

methodsUsing United States Renal Data System and Scientific Registry for Transplant Research data, we compared access to kidney transplantation (KT), time from ESRD to listing, time from listing to KT, and post-KT graft failure and death between donors and matched nondonors with ESRD.

resultsAmong 99 donors between April 1994 and November 2011 who developed ESRD, 78 initially received dialysis (of whom 37 listed for KT, 2 received live donor KT without listing, and 39 never listed for or received a KT), 20 listed preemptively (of whom 19 were subsequently transplanted), and 1 received a preemptive live donor KT without listing or ever receiving dialysis. Donors were listed earlier (median time to listing, 17 months vs 120 for nondonors; P < 0.001), received KT earlier (median waiting time, 2.8 months vs 21.5 for nondonors; P < 0.001), and received 13% live donor, 87% standard criteria, and 0% expanded criteria deceased donor KT (39%, 50%, and 11% in nondonors). Post-KT graft (adjusted hazard ratio, 1.9; 95% confidence interval, 0.9 to 4.1; P = 0.1) and patient (adjusted hazard ratio, 0.7; 95% confidence interval, 0.2 to 2.4; P = 0.5) survival were comparable in donors and nondonors.

conclusionsOur finding that 39 of 99 donors who developed ESRD never listed for a transplant warrants further study to ascertain why these donors with ESRD never gained access to the waiting list.

Indexed as

Living DonorsTreatment OutcomeAdolescentAdultFemaleGraft SurvivalHumansKidney Failure, ChronicKidney TransplantationMaleMiddle AgedNephrectomyPostoperative ComplicationsProportional Hazards ModelsRegistriesTime Factors

Identifiers

PMID26457599
PMCPMC4826649
OpenAlexW2329203618

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.