Evidence map›Paper›PMID 26457326›Full record

ArticleScience advances2015

Cystic fibrosis-adapted

Shantelle L LaFayette, Daniel Houle, Trevor Beaudoin, Gabriella Wojewodka, Danuta Radzioch, Lucas R Hoffman, Jane L Burns, Ajai A Dandekar, Nicole E Smalley, Josephine R Chandler and 7 more

Open access · goldAbstract read
In one paragraph

Article in Science advances, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 84 papers.

0numbers the graph read from it
0cells of the map it votes in
84citing papers in PubMed
4.7field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

84 citing papers in PubMed, 128 citations in OpenAlex.

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  16. Phage-host interaction inApplied and environmental microbiology · 2025
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24 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 6 institutions in 2 countries.

Shantelle L LaFayetteDepartment of Microbiology and Immunology, McGill University, Montreal, Quebec H3A, 2B4 Canada.
Daniel HouleDepartment of Medicine, Research Institute of the McGill University Health Centre, Montreal, Quebec H4A 3J1, Canada.
Trevor BeaudoinDepartment of Medicine, Research Institute of the McGill University Health Centre, Montreal, Quebec H4A 3J1, Canada.
Gabriella WojewodkaDepartment of Medicine, Research Institute of the McGill University Health Centre, Montreal, Quebec H4A 3J1, Canada.
Danuta RadziochDepartment of Medicine, Research Institute of the McGill University Health Centre, Montreal, Quebec H4A 3J1, Canada.
Lucas R HoffmanDepartment of Microbiology, University of Washington, Seattle, WA 98195, USA ; Department of Pediatrics, University of Washington, Seattle, WA 98195, USA.
Jane L BurnsDepartment of Pediatrics, University of Washington, Seattle, WA 98195, USA.
Ajai A DandekarDepartment of Microbiology, University of Washington, Seattle, WA 98195, USA.
Nicole E SmalleyDepartment of Microbiology, University of Washington, Seattle, WA 98195, USA.
Josephine R ChandlerDepartment of Molecular Biosciences, University of Kansas, Lawrence, KS 66045, USA.
James E ZlosnikDepartment of Pediatrics, University of British Columbia, Vancouver, British Columbia V5Z 4H4, Canada.
David P SpeertDepartment of Pediatrics, University of British Columbia, Vancouver, British Columbia V5Z 4H4, Canada.
Joanie BernierMcGill University Health Centre, Montreal, Quebec H4A 3J1, Canada.
Elias MatoukMcGill University Health Centre, Montreal, Quebec H4A 3J1, Canada.
Emmanuelle BrochieroCentre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM), Montreal, Quebec H2X 0A9, Canada.
Simon RousseauDepartment of Medicine, Research Institute of the McGill University Health Centre, Montreal, Quebec H4A 3J1, Canada.
Dao NguyenDepartment of Microbiology and Immunology, McGill University, Montreal, Quebec H3A, 2B4 Canada ; Department of Medicine, Research Institute of the McGill University Health Centre, Montreal, Quebec H4A 3J1, Canada ; McGill University Health Centre, Montreal, Quebec H4A 3J1, Canada.
McGill University Health Centre · CAUniversity of Washington · USUniversity of British Columbia · CACentre Hospitalier de l’Université de Montréal · CAMcGill University · CAUniversity of Kansas · US

Funding

Translational Research Center to Expedite Novel Therapies in Cystic FibrosisP30DK089507 · NIDDK · SEATTLE CHILDREN'S HOSPITAL · PI Sonya Heltshe · 2010 to 2026
$21.4M
Pseudomonas aeruginosa Adaptation During Early CF Airway Infection and TreatmentR01HL098084 · NHLBI · UNIVERSITY OF WASHINGTON · PI HOFFMAN, LUCAS R · 2009 to 2012
$1.6M
Mechanisms to restrain social cheating from quorum sensing in Pseudomonas aeruginK08AI102921 · NIAID · UNIVERSITY OF WASHINGTON · PI DANDEKAR, AJAI · 2013 to 2016
$703k
Pseudomonas Aeruginosa Early CF Adaptive Changes: A Translational StudyK02HL105543 · NHLBI · UNIVERSITY OF WASHINGTON · PI HOFFMAN, LUCAS R · 2011 to 2014
$400k
NHLBI NIH HHS K02 HL105543NHLBI NIH HHS R01 HL098084NIAID NIH HHS K08 AI102921NIDDK NIH HHS P30 DK089507
6 · The paper itself

Abstract

Cystic fibrosis lung disease is characterized by chronic airway infections with the opportunistic pathogen

Identifiers

PMID26457326
PMCPMC4597794
OpenAlexW2192402885

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.