Evidence map›Paper›PMID 26457324›Full record

ArticleeNeuro

Modulation of a Single Neuron Has State-Dependent Actions on Circuit Dynamics

Gabrielle J Gutierrez, Eve Marder

Abstract read
In one paragraph

Article in eNeuro. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Neuronal Switching between Single- and Dual-Network Activity via Modulation of Intrinsic Membrane Properties.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021
    Article
  7. Dopamine Transporter Is a Master Regulator of Dopaminergic Neural Network Connectivity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021
    Article
  8. Contributions of h- and NaFrontiers in cellular neuroscience · 2021
    Article
  9. Article
  10. Article
  11. Review
  12. Review
  13. Serotonin Disinhibits aThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2018
    Article
  14. Review
  15. Article
  16. Review
  17. Consequences of degeneracy in network function.Current opinion in neurobiology · 2016
    Review
  18. Analysis of complex neural circuits with nonlinear multidimensional hidden state models.Proceedings of the National Academy of Sciences of the United States of America · 2016
    Article
  19. Review
  20. Animal-to-Animal Variability in Neuromodulation and Circuit Function.Cold Spring Harbor symposia on quantitative biology · 2014
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Gabrielle J GutierrezVolen Center for Complex Systems and Biology Department, Brandeis University, Waltham, Massachusetts 02454.
Eve MarderVolen Center for Complex Systems and Biology Department, Brandeis University, Waltham, Massachusetts 02454.

Funding

Variability and Compensation in Reliable Neuronal NetworksR01MH046742 · NIMH · BRANDEIS UNIVERSITY · PI MARDER, EVE E · 1990 to 2025
$7.8M
NEUROTRANSMITTER MODULATION OF NEURONAL CIRCUITSR01NS017813 · NINDS · BRANDEIS UNIVERSITY · PI MARDER, EVE E · 1985 to 2009
$3.3M
Neurotransmitter Modulation of Neuronal CircuitsR37NS017813 · NINDS · BRANDEIS UNIVERSITY · PI MARDER, EVE E · 2010 to 2016
$2.6M
INTRINSIC PLASTICITY IN OSCILLATORY NEURAL NETWORKSR37MH046742 · NIMH · BRANDEIS UNIVERSITY · PI MARDER, EVE E · 1995 to 2004
$1.5M
NIMH NIH HHS R01 MH046742NIMH NIH HHS R37 MH046742NINDS NIH HHS R01 NS017813NINDS NIH HHS R37 NS017813
6 · The paper itself

Abstract

When does neuromodulation of a single neuron influence the output of the entire network? We constructed a five-cell circuit in which a neuron is at the center of the circuit and the remaining neurons form two distinct oscillatory subnetworks. All neurons were modeled as modified Morris-Lecar models with a hyperpolarization-activated conductance (

Indexed as

connectomeCPGelectrical couplinghalf-center oscillatorh-conductanceMorris–Lecar model

Identifiers

PMID26457324
PMCPMC4596081

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.