ArticleBioImpacts : BI2015
A prospective highlight on exosomal nanoshuttles and cancer immunotherapy and vaccination.
Article in BioImpacts : BI, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 18 citations in OpenAlex.
- Unlocking the potential: current landscape and future directions of immunotherapy in gastric cancer.Frontiers in immunology · 2026Review
- Exosome-based cancer vaccine: a cell-free approach.Molecular biology reports · 2025Review
- The role of tumor microenvironment and self-organization in cancer progression: Key insights for therapeutic development.BioImpacts : BI · 2025Review
- Role of exosomes in the development, diagnosis, prognosis and treatment of hepatocellular carcinoma.Molecular medicine (Cambridge, Mass.) · 2023Review
- Achievements and beyond: Scientific trajectory of Professor Mohammad A. Rafi.BioImpacts : BI · 2021Article
- Tumor-derived extracellular vesicles: insights into bystander effects of exosomes after irradiation.Lasers in medical science · 2020Review
- Stimuli-responsive chitosan-based nanocarriers for cancer therapy.BioImpacts : BI · 2017Review
- Molecular machineries of pH dysregulation in tumor microenvironment: potential targets for cancer therapy.BioImpacts : BI · 2017Review
- Blood-brain barrier transport machineries and targeted therapy of brain diseases.BioImpacts : BI · 2016Review
- Network of nanomedicine researches: impact of Iranian scientists.BioImpacts : BI · 2015Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionExosomes (EXOs) and ectosomes (ECTOs) are nanoscale membranous extracellular vesicles (EVs) derived from different cells mediating various cellular communications. EXOs are liberated based on the exocytosis of multivesicular bodies, while ECTOs are ubiquitously released from the plasma membranes.
methodsHere, in this paper, we go over the extracellular vesicular machineries and concisely highlight their clinical importance in solid tumors and their possible applications in cancer immunotherapy/vaccination.
resultsIn various types of cancers, these vesicles play central roles delivering cancer cell messages to the target cells, as a result both of them seem to provide a novel useful means for diagnosis and therapy of malignancies. Dendritic cell-derived exosomes (DEXOs) are able to activate the tumor antigen-specific CD8(+) cytotoxic T-lymphocytes (CTLs) and hence induce antitumor responses in vivo. Within the tumor microenvironment (TME), however, tumor cells seem to generate exosomes (the so-called oncosoems) that may act in favor of tumor progression.
conclusionsAs complex systems, these vesicular micro-/nano-machines convey important cellular messages dependent upon the cells/tissue setting(s). In addition to their potential in diagnosis of cancers, they have been exploited for cancer immunotherapy/vaccination. However, such treatment strategies need to be carefully designed to attain desired clinical outcomes.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.