ArticleNeural plasticity2015
Plasticity-Related PKMζ Signaling in the Insular Cortex Is Involved in the Modulation of Neuropathic Pain after Nerve Injury.
Article in Neural plasticity, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 28 citations in OpenAlex.
- Targeting the insular cortex for neuropathic pain modulation: Insights into synaptic and neuronal mechanisms.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025Article
- Deciphering the functional role of insular cortex stratification in trigeminal neuropathic pain.The journal of headache and pain · 2024Review
- DNA Methylation Changes in Blood Cells of Fibromyalgia and Chronic Fatigue Syndrome Patients.Journal of pain research · 2023Article
- Modulation of Neuropathic Pain by Glial Regulation in the Insular Cortex of Rats.Frontiers in molecular neuroscience · 2022Article
- Current Understanding of the Involvement of the Insular Cortex in Neuropathic Pain: A Narrative Review.International journal of molecular sciences · 2021Review
- Neuronal Adenylyl Cyclase Targeting Central Plasticity for the Treatment of Chronic Pain.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2020Review
- Anterior insular cortex mediates hyperalgesia induced by chronic pancreatitis in rats.Molecular brain · 2019Article
- Review
- NMDA Receptor Dependent Long-term Potentiation in Chronic Pain.Neurochemical research · 2019Review
- Plasticity changes in forebrain activity and functional connectivity during neuropathic pain development in rats with sciatic spared nerve injury.Molecular brain · 2018Article
- PKMζ Is Not Required for Development of Postsurgical Pain.Molecular neurobiology · 2018Article
- The analgesic effect of trans-resveratrol is regulated by calcium channels in the hippocampus of mice.Metabolic brain disease · 2017Article
- Calcium-stimulated adenylyl cyclase subtype 1 (AC1) contributes to LTP in the insular cortex of adult mice.Heliyon · 2017Article
- Neonatal Maternal Deprivation Enhances Presynaptic P2X7 Receptor Transmission in Insular Cortex in an Adult Rat Model of Visceral Hypersensitivity.CNS neuroscience & therapeutics · 2017Article
- The Effect of Electroacupuncture on PKMzeta in the ACC in Regulating Anxiety-Like Behaviors in Rats Experiencing Chronic Inflammatory Pain.Neural plasticity · 2017Article
- Inhibition of Mammalian Target of Rapamycin (mTOR) Signaling in the Insular Cortex Alleviates Neuropathic Pain after Peripheral Nerve Injury.Frontiers in molecular neuroscience · 2017Article
- Top-Down Cortical Control of Acute and Chronic Pain.Psychosomatic medicineArticle
- Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The insular cortex (IC) is associated with important functions linked with pain and emotions. According to recent reports, neural plasticity in the brain including the IC can be induced by nerve injury and may contribute to chronic pain. Continuous active kinase, protein kinase Mζ (PKMζ), has been known to maintain the long-term potentiation. This study was conducted to determine the role of PKMζ in the IC, which may be involved in the modulation of neuropathic pain. Mechanical allodynia test and immunohistochemistry (IHC) of zif268, an activity-dependent transcription factor required for neuronal plasticity, were performed after nerve injury. After ζ-pseudosubstrate inhibitory peptide (ZIP, a selective inhibitor of PKMζ) injection, mechanical allodynia test and immunoblotting of PKMζ, phospho-PKMζ (p-PKMζ), and GluR1 and GluR2 were observed. IHC demonstrated that zif268 expression significantly increased in the IC after nerve injury. Mechanical allodynia was significantly decreased by ZIP microinjection into the IC. The analgesic effect lasted for 12 hours. Moreover, the levels of GluR1, GluR2, and p-PKMζ were decreased after ZIP microinjection. These results suggest that peripheral nerve injury induces neural plasticity related to PKMζ and that ZIP has potential applications for relieving chronic pain.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.