ReviewInternational journal of endocrinology2015
Comorbidity between Type 2 Diabetes and Depression in the Adult Population: Directions of the Association and Its Possible Pathophysiological Mechanisms.
Review in International journal of endocrinology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
43 citing papers in PubMed, 1 synthesis or guideline pooled it, 91 citations in OpenAlex.
- Pooled it
- To assess the impact of individualized strategy and continuous glucose monitoring on glycemic control and mental health in pregnant women with diabetes.Frontiers in endocrinology · 2025Trial
- The interplay between loneliness, cortisol, and NK cell function: The role of cortisol in NK cell dysfunction.Psychoneuroendocrinology · 2026Article
- Association between dietary self-care adherence and depression among adults living with type 2 diabetes mellitus in Ghana: a cross-sectional study.Journal of health, population, and nutrition · 2025Article
- The Association Between Depression and Antidiabetic Treatments in Type 2 Diabetes Patients with Both Good and Poor Glycemic Control.Journal of clinical medicine · 2025Article
- Antidepressive and anxiolytic effects of a combination of Saffron and Chamomile in rats and their relationship with serotonin using methods.Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan · 2025Article
- Article
- Diabetes Mellitus Inequality in South Korean Adults by Region: The Influence of Obesity and Depression.Iranian journal of public health · 2024Article
- Predictive Factors of Anxiety and Depression in Patients with Type 2 Diabetes Mellitus.Journal of clinical medicine · 2024Article
- Depressive disorder, bipolar disorder, and associated factors among adults, in the Eastern part of Ethiopia.BMC psychiatry · 2024Article
- Aerobic Exercise Improves the Overall Outcome of Type 2 Diabetes Mellitus Among People With Mental Disorders.Depression and anxiety · 2024Review
- Glycemic indicators and mental health symptoms: results from the greater Beirut area cardiovascular cohort.Frontiers in endocrinology · 2024Article
- Sex- and age-specific prevalence and risk factors of depressive symptoms in Parkinson's disease.Journal of neural transmission (Vienna, Austria : 1996) · 2023Article
- Effectiveness and safety of traditional Chinese medicine for diabetic retinopathy: A systematic review and network meta-analysis of randomized clinical trials.World journal of diabetes · 2023Article
- The Association between Type-1 Diabetes Mellitus and Risk of Depression among Saudi Patients: A Cross-Sectional Study.Journal of personalized medicine · 2023Article
- Interactions of Apigenin and Safranal with the 5HT1A and 5HT2A Receptors and Behavioral Effects in Depression and Anxiety: A Molecular Docking, Lipid-Mediated Molecular Dynamics, and In Vivo Analysis.Molecules (Basel, Switzerland) · 2022Article
- Comorbidity of NovelInternational journal of molecular sciences · 2022Article
- The Effects of Stress on Glycemic Control Brought on by Changes in Social Conditions Due to COVID-19.Internal medicine (Tokyo, Japan) · 2021Article
- Healthy diet, depression and quality of life: A narrative review of biological mechanisms and primary prevention opportunities.World journal of psychiatry · 2021Review
- Characterizing Multimorbidity from Type 2 Diabetes: Insights from Clustering Approaches.Endocrinology and metabolism clinics of North America · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Type 2 diabetes and depression are regarded as comorbid conditions, and three possible directions of the association between the diseases can underlie this observation of comorbidity. First, common etiology can increase a person's risk of both diseases; second, persons with type 2 diabetes have increased prevalence or risk of future development of depression; or third, persons with depression have increased prevalence or risk of development of type 2 diabetes. This review gives an overview over possible pathophysiological mechanisms for each of the directions of the association between type 2 diabetes and depression and further discusses epigenetics as an additional, direction independent approach. We argue that unspecific pathophysiological mechanisms involved in the stress response might, at least to some extent, explain each of the directions of the association between type 2 diabetes and depression, while changes in brain structure and function among persons with diabetes and possible increased risk of development of type 2 diabetes after use of antidepressant agents could represent more disease specific mechanisms underlying the comorbidity.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.