ArticleEarly intervention in psychiatry2017
Anxiety in youth at clinical high risk for psychosis.
Article in Early intervention in psychiatry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
41 citing papers in PubMed, 1 synthesis or guideline pooled it, 77 citations in OpenAlex.
- Interventions for prodromal stage of psychosis.The Cochrane database of systematic reviews · 2019Pooled it
- Family communication and the efficacy of family focused therapy in individuals at clinical high risk for psychosis with comorbid anxiety.Early intervention in psychiatry · 2023Trial
- Exercise Intervention in Individuals at Clinical High Risk for Psychosis: Benefits to Fitness, Symptoms, Hippocampal Volumes, and Functional Connectivity.Schizophrenia bulletin · 2022Trial
- Effects of the Health-Awareness-Strengthening Lifestyle Program in a Randomized Trial of Young Adults with an At-Risk Mental State.International journal of environmental research and public health · 2021Trial
- Psychotic vulnerability in pediatric obsessive-compulsive disorder: associations with clinical features and treatment outcome in two clinical samples.European child & adolescent psychiatry · 2025Article
- Multisensory integration of affective faces and voices in psychosis proneness.Schizophrenia (Heidelberg, Germany) · 2025Article
- Exploring the Working Mechanisms between Anxiety, Mental Imagery, and Auditory Verbal Hallucinations: A Longitudinal Study.Schizophrenia bulletin open · 2025Article
- Baseline Clinical Characterization of Participants in the Accelerating Medicines Partnership Schizophrenia Program.Schizophrenia bulletin open · 2025Article
- Fear and Anxiety in Schizophrenia: A Focus on Development, Assessment, and Mechanisms.Current topics in behavioral neurosciences · 2025Review
- Psychiatric Adverse Effects From Prucalopride in a Medically Complex Adolescent.Case reports in pediatrics · 2025Article
- Psychological and social difficulties in young non-help-seeking adolescents at risk for psychosis: insights from a large cohort study.Frontiers in psychology · 2024Article
- Development of the Delusional Interpretation Scale and examination of related variables.PCN reports : psychiatry and clinical neurosciences · 2023Article
- Clinical high risk for psychosis syndrome is associated with reduced neural responding to unpleasant images.Journal of psychopathology and clinical science · 2023Article
- Characterizing sustained social anxiety in individuals at clinical high risk for psychosis: trajectory, risk factors, and functional outcomes.Psychological medicine · 2023Article
- Self-reported Gesture Interpretation and Performance Deficits in Individuals at Clinical High Risk for Psychosis.Schizophrenia bulletin · 2023Article
- Skills program for awareness, connectedness, and empowerment: A conceptual framework of a skills group for individuals with a psychosis-risk syndrome.Frontiers in psychiatry · 2023Article
- Patient-Reported Outcome Measures in Clinical High Risk for Psychosis: A Systematic Review.Schizophrenia bulletin open · 2023Review
- Evaluating the Social Functioning Scale modified for use in individuals at clinical high-risk for psychosis.Schizophrenia research · 2022Article
- Impact of Comorbid Affective Disorders on Longitudinal Clinical Outcomes in Individuals at Ultra-high Risk for Psychosis.Schizophrenia bulletin · 2022Article
- Efficiency of an Online Health-Promotion Program in Individuals with At-Risk Mental State during the COVID-19 Pandemic.International journal of environmental research and public health · 2021Article
Corrections and comments
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Authors and funding
15 authors at 10 institutions in 3 countries.
Funding
Abstract
aimHigh rates of anxiety have been observed in youth at clinical high risk (CHR) of developing psychosis. In CHR, anxiety often co-occurs with depression, and there is inconsistent evidence on anxiety in relation to transition to psychosis. The aim of this study was to examine: (i) the prevalence of anxiety disorders in individuals at CHR; (ii) clinical differences between those with and without anxiety; and (iii) the association of baseline anxiety with later transition to psychosis.
methodsThe sample consisted of 765 CHR individuals and 280 healthy controls. CHR status was determined with the Structured Interview of Prodromal Syndromes, mood and anxiety diagnoses with the Structured Clinical Interview for DSM-IV Disorders, and severity of anxiety with the Social Interaction Anxiety Scale and Self-Rating Anxiety Scale.
resultsIn the CHR sample, 51% met criteria for an anxiety disorder. CHR participants had significantly more anxiety diagnoses and severity than healthy controls. Anxiety was correlated to attenuated psychotic and negative symptoms in CHR and those with an anxiety disorder demonstrated more suspiciousness. CHR participants with obsessive-compulsive disorder (OCD) exhibited more severe symptomatology than those without OCD. An initial presentation of anxiety did not differ between those who did or did not transition to psychosis.
conclusionsIn this large sample of individuals at CHR, anxiety is common and associated with more severe attenuated psychotic symptoms. Treatment not only to prevent or delay transition to psychosis but also to address presenting concerns, such as anxiety, is warranted.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.