Evidence map›Paper›PMID 26456876›Full record

Trial reportAmerican journal of preventive medicine2016

Cardiovascular Health and Incident Cardiovascular Disease and Cancer: The Women's Health Initiative.

Randi E Foraker, Mahmoud Abdel-Rasoul, Lewis H Kuller, Rebecca D Jackson, Linda Van Horn, Rebecca A Seguin, Monika M Safford, Robert B Wallace, Anna M Kucharska-Newton, Jennifer G Robinson and 5 more

Registry-linked trialAbstract readClinical TrialObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Trial report in American journal of preventive medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03935282 (Assessing Effectiveness and Implementation of an EHR Tool to Assess Heart Health Among Survivors), which is not on this map. Cited by 47 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
47citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03935282 nacompletednot on this mapstarted 2020, after this paper: background citation

Assessing Effectiveness and Implementation of an EHR Tool to Assess Heart Health Among Survivors (AH-HA)

TypeinterventionalSponsorWake Forest University Health SciencesRan2020 to 2025Enrolled645ConditionsBreast Neoplasm, Prostatic Neoplasm, Colorectal Neoplasms, Endometrial NeoplasmsArmsAH-HA Tool in the EPIC EHR
3 · Its place in the literature

Who cites it

47 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
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  9. Observational
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  15. Association of Ideal Cardiovascular Health in Youth with Cancer Risk in Adulthood: A Cardiovascular Risk in Young Finns Study.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2024
    Article
  16. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Randi E ForakerDivision of Epidemiology, The Ohio State University, Columbus, Ohio. Electronic address: rforaker@cph.osu.edu.
Mahmoud Abdel-RasoulCenter for Biostatistics, The Ohio State University, Columbus, Ohio.
Lewis H KullerDepartment of Epidemiology, University of Pittsburgh, Pittsburgh, Pennsylvania.
Rebecca D JacksonDepartment of Internal Medicine, The Ohio State University, Columbus, Ohio.
Linda Van HornDepartment of Preventive Medicine, Northwestern University, Chicago, Illinois.
Rebecca A SeguinDivision of Nutritional Sciences, Cornell University, Ithaca, New York.
Monika M SaffordDepartment of Medicine, University of Alabama at Birmingham, Birmingham, Alabama.
Robert B WallaceDepartment of Epidemiology, The University of Iowa, Iowa City, Iowa.
Anna M Kucharska-NewtonDepartment of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.
Jennifer G RobinsonDepartment of Epidemiology, The University of Iowa, Iowa City, Iowa.
Lisa W MartinDepartment of Medicine, The George Washington University, Washington, District of Columbia.
Golareh AghaDepartment of Environmental Health, Harvard University, Cambridge, Massachusetts;
Lifang HouDepartment of Preventive Medicine, Northwestern University, Chicago, Illinois.
Norrina B AllenDepartment of Preventive Medicine, Northwestern University, Chicago, Illinois.
Hilary A TindleDepartment of Medicine, Vanderbilt University, Nashville, Tennessee.

Funding

Tumor Environment and Metastasis (TEAM) Research ProgramP30CA060553 · NCI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Daniela E Matei · 1993 to 2026
$153.9M
Translational Therapeutics Research Program (TT)P30CA016058 · NCI · OHIO STATE UNIVERSITY · PI Tasleem J Padamsee · 1985 to 2026
$132.3M
Pulmonary Toxicology Facility CoreP30ES005605 · NIEHS · UNIVERSITY OF IOWA · PI Brandi Janssen · 1990 to 2026
$40.5M
NCI NIH HHS P30 CA016058NCI NIH HHS P30 CA060553NHLBI NIH HHS HHSN268201100001INHLBI NIH HHS HHSN268201100002INHLBI NIH HHS HHSN268201100003INHLBI NIH HHS HHSN268201100004INHLBI NIH HHS HHSN268201100046CNIA NIH HHS HHSN271201100004CNIEHS NIH HHS P30 ES005605WHI NIH HHS HHSN268201100001CWHI NIH HHS HHSN268201100002CWHI NIH HHS HHSN268201100003CWHI NIH HHS HHSN268201100004C
6 · The paper itself

Abstract

introductionThe American Heart Association's "Simple 7" offers a practical public health conceptualization of cardiovascular health (CVH). CVH predicts incident cardiovascular disease (CVD) in younger populations, but has not been studied in a large, diverse population of aging postmenopausal women. The extent to which CVH predicts cancer in postmenopausal women is unknown.

methodsMultivariable Cox regression estimated hazard ratios and 95% CIs for the association between CVH and incident CVD, any cancer, and cancer subtypes (lung, colorectal, and breast) among 161,809 Women's Health Initiative observational study and clinical trial participants followed from 1993 through 2010. Data were analyzed in 2013. CVH score was characterized as the number (0 [worst] to 7 [best]) of the American Heart Association's ideal CVH behaviors and factors at baseline: smoking, BMI, physical activity, diet, total cholesterol, blood pressure, and fasting glucose.

resultsMedian follow-up was approximately 13 years. Fewer minorities and less educated women achieved ideal CVH, a common benchmark. In adjusted models, compared with women with the highest (best) CVH scores, those with the lowest (worst) CVH scores had nearly seven times the hazard of incident CVD (6.83, 95% CI=5.83, 8.00) and 52% greater risk of incident cancer (1.52, 95% CI=1.35, 1.72). Ideal CVH was most strongly inversely associated with lung cancer, then colorectal cancer, and then breast cancer.

conclusionsLower ideal CVH is more common among minority and less educated postmenopausal women and predicts increased risk of CVD and cancer in this population, emphasizing the importance of prevention efforts among vulnerable older adults.

Indexed as

Health StatusWomen's HealthAgedAged, 80 and overBlood GlucoseBlood PressureBody Mass IndexCardiovascular DiseasesCholesterolDietExerciseFemaleHealth BehaviorHumansMiddle AgedNeoplasmsBlood GlucoseCholesterol

Identifiers

PMID26456876
PMCPMC4718741

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.