ArticleNature communications2015
Ape parasite origins of human malaria virulence genes.
Article in Nature communications, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
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Who cites it
31 citing papers in PubMed, 50 citations in OpenAlex.
- Hidden hematological, biochemical and immune costs of asymptomatic malaria infections in semi-wild chimpanzees.PLoS pathogens · 2026Article
- Apicoplast-Resident Processes: Exploiting the Chink in the Armour ofAdvances in pharmacological and pharmaceutical sciences · 2024Review
- Malaria Genomics, Vaccine Development, and Microbiome.Pathogens (Basel, Switzerland) · 2023Review
- Bayesian estimation of community size and overlap from random subsamples.PLoS computational biology · 2022Article
- Associations between Afrotropical bats, eukaryotic parasites, and microbial symbionts.Molecular ecology · 2022Article
- Varia: a tool for prediction, analysis and visualisation of variable genes.BMC bioinformatics · 2022Article
- Malaria in the 'Omics Era'.Genes · 2021Review
- Evolutionary analyses of the major variant surface antigen-encoding genes reveal population structure of Plasmodium falciparum within and between continents.PLoS genetics · 2021Article
- Article
- Naturally Acquired Humoral Immunity AgainstFrontiers in immunology · 2020Review
- VAR2CSA-Mediated Host Defense Evasion ofFrontiers in immunology · 2020Review
- VAR2CSA binding phenotype has ancient origin and arose before Plasmodium falciparum crossed to humans: implications in placental malaria vaccine design.Scientific reports · 2019Article
- Evaluating 18s-rRNA LAMP and selective whole genome amplification (sWGA) assay in detecting asymptomatic Plasmodium falciparum infections in blood donors.Malaria journal · 2019Article
- Competition for hosts modulates vast antigenic diversity to generate persistent strain structure in Plasmodium falciparum.PLoS biology · 2019Article
- Mapping malaria by combining parasite genomic and epidemiologic data.BMC medicine · 2018Article
- Genomes of all known members of a Plasmodium subgenus reveal paths to virulent human malaria.Nature microbiology · 2018Article
- Networks of genetic similarity reveal non-neutral processes shape strain structure in Plasmodium falciparum.Nature communications · 2018Article
- The Plasmodium falciparum transcriptome in severe malaria reveals altered expression of genes involved in important processes including surface antigen-encoding var genes.PLoS biology · 2018Article
- The Molecular Basis of Erythrocyte Invasion by Malaria Parasites.Cell host & microbe · 2017Review
- Variant surface antigens of Plasmodium falciparum and their roles in severe malaria.Nature reviews. Microbiology · 2017Review
Corrections and comments
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Authors and funding
12 authors at 6 institutions in 2 countries.
Funding
Abstract
Antigens encoded by the var gene family are major virulence factors of the human malaria parasite Plasmodium falciparum, exhibiting enormous intra- and interstrain diversity. Here we use network analysis to show that var architecture and mosaicism are conserved at multiple levels across the Laverania subgenus, based on var-like sequences from eight single-species and three multi-species Plasmodium infections of wild-living or sanctuary African apes. Using select whole-genome amplification, we also find evidence of multi-domain var structure and synteny in Plasmodium gaboni, one of the ape Laverania species most distantly related to P. falciparum, as well as a new class of Duffy-binding-like domains. These findings indicate that the modular genetic architecture and sequence diversity underlying var-mediated host-parasite interactions evolved before the radiation of the Laverania subgenus, long before the emergence of P. falciparum.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.