ArticleScientific reports2015
Modification of the association between maternal smoke exposure and congenital heart defects by polymorphisms in glutathione S-transferase genes.
Article in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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12 citing papers in PubMed, 36 citations in OpenAlex.
- Using Residual Newborn Blood Spots to Investigate CpG Methylation in Relation to Air Pollution and Congenital Heart Defects.Birth defects research · 2025Article
- Amniotic fluid microbiota and metabolism with non-syndromic congenital heart defects: a multi-omics analysis.BMC pregnancy and childbirth · 2025Article
- Association of maternal phthalates exposure and metabolic gene polymorphisms with congenital heart diseases: a multicenter case-control study.BMC pregnancy and childbirth · 2024Article
- Maternal Exposure to PMCirculation · 2023Article
- Biomarkers for isolated congenital heart disease based on maternal amniotic fluid metabolomics analysis.BMC cardiovascular disorders · 2022Article
- Association between maternal smoke exposure and congenital heart defects from a case-control study in China.Scientific reports · 2022Article
- Parental risk factors associated with congenital heart disease in a Thai population: multivariable analysis.Asian biomedicine : research, reviews and news · 2021Article
- Association between prepregnancy body mass index and risk of congenital heart defects in offspring: an ambispective observational study in China.BMC pregnancy and childbirth · 2020Observational
- Influence of Second-Hand Smoke and Prenatal Tobacco Smoke Exposure on Biomarkers, Genetics and Physiological Processes in Children-An Overview in Research Insights of the Last Few Years.International journal of environmental research and public health · 2020Review
- Environmental Contaminants and Congenital Heart Defects: A Re-Evaluation of the Evidence.International journal of environmental research and public health · 2018Review
- Assessment of interaction between maternal polycyclic aromatic hydrocarbons exposure and genetic polymorphisms on the risk of congenital heart diseases.Scientific reports · 2018Article
- Congenital heart defects of fetus after maternal exposure to organic and inorganic environmental factors: a cohort study.Oncotarget · 2017Article
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Authors and funding
14 authors at 6 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Congenital heart defects (CHDs) arise through various combinations of genetic and environmental factors. Our study explores how polymorphisms in the glutathione S-transferase (GST) genes affect the association between cigarette smoke exposure and CHDs. We analysed 299 mothers of children with CHDs and 284 mothers of children without any abnormalities who were recruited from six hospitals. The hair nicotine concentration (HNC) was used to quantify maternal smoke exposure, and the maternal GSTT1, and GSTM1 and GSTP1 genes were sequenced. We found a trend of higher adjusted odds ratios with higher maternal HNC levels, suggesting a dose-response relationship between maternal smoke exposure and CHDs. The lowest HNC range associated with an increased risk of CHDs was 0.213-0.319 ng/mg among the mothers with functional deletions of GSTM1 or GSTT1and 0.319-0.573 ng/mg among the mothers with normal copies of GSTM1 and GSTT1. In addition, the adjusted odds ratio for an HNC of >0.573 ng/mg was 38.53 among the mothers with the GSTP1 AG or GG genotype, which was 7.76 (χ(2) = 6.702, p = 0.010) times greater than the AOR in the mothers with GSTP1 AA genotype. Our study suggests that polymorphisms of maternal GST genes may modify the association of maternal smoke exposure with CHDs.
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