ReviewCurrent topics in medicinal chemistry2016
Linking Biosynthetic Gene Clusters to their Metabolites via Pathway- Targeted Molecular Networking.
Review in Current topics in medicinal chemistry, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed.
- Article
- UPLC-Q-TOF-MS/MS Analysis ofFrontiers in microbiology · 2022Article
- Emerging Molecular Tools for Engineering Phytomicrobiome.Indian journal of microbiology · 2021Review
- Diversity, novelty, antimicrobial activity, and new antibiotics of cultivable endophytic actinobacteria isolated from psammophytes collected from Taklamakan Desert.Journal of pharmaceutical analysis · 2021Article
- Employing chemical synthesis to study the structure and function of colibactin, a "dark matter" metabolite.Natural product reports · 2020Review
- Reproducible molecular networking of untargeted mass spectrometry data using GNPS.Nature protocols · 2020Article
- Depurination of Colibactin-Derived Interstrand Cross-Links.Biochemistry · 2020Article
- Synthesis and reactivity of precolibactin 886.Nature chemistry · 2019Article
- Structure elucidation of colibactin and its DNA cross-links.Science (New York, N.Y.) · 2019Article
- Model Colibactins Exhibit Human Cell Genotoxicity in the Absence of Host Bacteria.ACS chemical biology · 2018Article
- Characterization of Natural Colibactin-Nucleobase Adducts by Tandem Mass Spectrometry and Isotopic Labeling. Support for DNA Alkylation by Cyclopropane Ring Opening.Biochemistry · 2018Article
- Marine Mammal Microbiota Yields Novel Antibiotic with Potent Activity Against Clostridium difficile.ACS infectious diseases · 2018Article
- Molecular Basis of Gut Microbiome-Associated Colorectal Cancer: A Synthetic Perspective.Journal of the American Chemical Society · 2017Review
- Nonribosomal peptide synthetase biosynthetic clusters of ESKAPE pathogens.Natural product reports · 2017Review
- Symbiosis-inspired approaches to antibiotic discovery.Natural product reports · 2017Review
- Domain-Targeted Metabolomics Delineates the Heterocycle Assembly Steps of Colibactin Biosynthesis.Journal of the American Chemical Society · 2017Article
- Natural products as mediators of disease.Natural product reports · 2017Review
- Comparative mass spectrometry-based metabolomics strategies for the investigation of microbial secondary metabolites.Natural product reports · 2017Review
- A Mechanistic Model for Colibactin-Induced Genotoxicity.Journal of the American Chemical Society · 2016Article
- Convergent and Modular Synthesis of Candidate Precolibactins. Structural Revision of Precolibactin A.Journal of the American Chemical Society · 2016Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
The connection of microbial biosynthetic gene clusters to the small molecule metabolites they encode is central to the discovery and characterization of new metabolic pathways with ecological and pharmacological potential. With increasing microbial genome sequence information being deposited into publicly available databases, it is clear that microbes have the coding capacity for many more biologically active small molecules than previously realized. Of increasing interest are the small molecules encoded by the human microbiome, as these metabolites likely mediate a variety of currently uncharacterized human-microbe interactions that influence health and disease. In this mini-review, we describe the ongoing biosynthetic, structural, and functional characterizations of the genotoxic colibactin pathway in gut bacteria as a thematic example of linking biosynthetic gene clusters to their metabolites. We also highlight other natural products that are produced through analogous biosynthetic logic and comment on some current disconnects between bioinformatics predictions and experimental structural characterizations. Lastly, we describe the use of pathway-targeted molecular networking as a tool to characterize secondary metabolic pathways within complex metabolomes and to aid in downstream metabolite structural elucidation efforts.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.