ArticleExperimental gerontology2015
Age differences in cytokine expression under conditions of health using experimental pain models.
Article in Experimental gerontology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 34 citations in OpenAlex.
- Effects of sub-chronic cannabis smoke exposure on inflammatory markers in serum and brain in younger and older mice.Neurobiology of aging · 2026Article
- The Associations Between Habitual Dietary Fat Intake and Inflammatory Markers Among Marathon Runners: An Exploratory Study.Nutrients · 2026Article
- Peripheral blood mRNA expression of IL37, IL1F10, and C17orf99 genes is altered in patients with B-acute lymphoblastic leukemia: a case-control study.Molecular biology reports · 2026Article
- Psychological and immunological associations with movement-evoked low back pain among older adults.Pain reports · 2025Article
- Exploring the Relationship Between Different Pain Patterns and Depressive Symptom Among Older Koreans: Using Latent Growth Model.Psychiatry investigation · 2025Article
- Through the Lens of Movement-Evoked Pain: A Theoretical Framework of the "Pain-Movement Interface" to Guide Research and Clinical Care for Musculoskeletal Pain Conditions.The journal of pain · 2024Review
- New perspectives on migraine treatment: a review of the mechanisms and effects of complementary and alternative therapies.Frontiers in neurology · 2024Review
- Circulating Inflammatory Biomarkers Predict Pain Change Following Exercise-Induced Shoulder Injury: Findings From the Biopsychosocial Influence on Shoulder Pain Preclinical Trial.The journal of pain · 2023Article
- Cytokines profile in neonatal and adult wild-type mice post-injection of U. S. pediatric vaccination schedule.Brain, behavior, & immunity - health · 2021Article
- eIF4E phosphorylation modulates pain and neuroinflammation in the aged.GeroScience · 2020Article
- Influence of seasonal changes on disease activity and distribution of affected joints in rheumatoid arthritis.BMC musculoskeletal disorders · 2019Observational
- Age Differences in the Time Course and Magnitude of Changes in Circulating Neuropeptides After Pain Evocation in Humans.The journal of pain · 2017Article
- Association Between Endometriosis and Hypercholesterolemia or Hypertension.Hypertension (Dallas, Tex. : 1979) · 2017Article
- Age differences in salivary markers of inflammation in response to experimental pain: does venipuncture matter?Journal of pain research · 2017Article
- Sex Differences in Interleukin-6 Responses Over Time Following Laboratory Pain Testing Among Patients With Knee Osteoarthritis.The journal of painArticle
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Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Older adults are at an increased risk to develop frequent and prolonged pain. Emerging evidence proposes a link between immune changes and pain, which is consistent with the inflammation theory of aging and the increased incidence of age-related diseases. This study tested the hypothesis that older adults show greater immune responses to experimental pain compared to younger individuals. Study subjects (8 younger and 9 older healthy adults) underwent 3 experimental sessions using well-validated human experimental pain models: the cold pressor task (CPT), focal heat pain (FHP), and a non-painful thermal control. Blood was collected through an indwelling catheter at baseline and 3, 15, 30, 45, 60, and 90 min post-stimuli administration. Pro-inflammatory cytokines (TNF-α IL-6 and IL-8) peaked at the same time points for both groups, with greater elevations among older subjects for TNF-α and IL-8 in both pain models and elevations in IL-6 only for CPT. Anti-inflammatory cytokines (IL-4, IL-5, and IL-10) generally peaked later for the older subjects, with increased elevations for FHP but not the CPT. These data are consistent with the assertion that age-related immune system dysregulation may account for the increased prevalence of pain in older adults.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.