Evidence map›Paper›PMID 26456445›Full record

ReviewPediatric clinics of North America2015

Gut Microbiome and the Development of Food Allergy and Allergic Disease.

Benjamin T Prince, Mark J Mandel, Kari Nadeau, Anne Marie Singh

Open access · greenAbstract readReview
In one paragraph

Review in Pediatric clinics of North America, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed
2.9field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed, 84 citations in OpenAlex.

  1. Article
  2. Microbiota and Microbiome.Progress in molecular and subcellular biology · 2026
    Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Review
  15. Review
  16. Review
  17. Observational
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Benjamin T PrinceDivision of Allergy and Immunology, Department of Pediatrics, Ann & Robert H. Lurie Children's Hospital of Chicago, Northwestern University, 225 East Chicago Avenue, #60, Chicago, IL 60611, USA; Division of Allergy and Immunology, Department of Medicine, Northwestern Feinberg School of Medicine, Northwestern University, 225 East Chicago Avenue, #60, Chicago, IL 60611, USA.
Mark J MandelDepartment of Microbiology-Immunology, Northwestern Feinberg School of Medicine, Northwestern University, Searle Building 3-403, 320 E. Superior Street, Chicago, IL 60611, USA.
Kari NadeauDivision of Allergy, Immunology, and Rheumatology, Department of Pediatrics, Stanford University School of Medicine, 730 Welch Rd, Stanford, CA 94305, USA.
Anne Marie SinghDivision of Allergy and Immunology, Department of Pediatrics, Ann & Robert H. Lurie Children's Hospital of Chicago, Northwestern University, 225 East Chicago Avenue, #60, Chicago, IL 60611, USA; Division of Allergy and Immunology, Department of Medicine, Northwestern Feinberg School of Medicine, Northwestern University, 225 East Chicago Avenue, #60, Chicago, IL 60611, USA. Electronic address: anne-singh@northwestern.edu.
Northwestern University · USLurie Children's Hospital · USStanford University · US

Funding

S. aureus and Regulatory T cells in the Failure of Oral ToleranceK23AI100995 · NIAID · UNIVERSITY OF WISCONSIN-MADISON · PI SINGH, ANNE MARIE · 2013 to 2017
$689k
NIAID NIH HHS K23 AI100995
6 · The paper itself

Abstract

The impact of gut microbiome on human development, nutritional needs, and disease has become evident with advances in the ability to study these complex communities of microorganisms, and there is growing appreciation for the role of the microbiome in immune regulation. Several studies have examined associations between changes in the commensal microbiota and the development of asthma, allergic rhinitis, and asthma, but far less have evaluated the impact of the microbiome on the development of food allergy. This article reviews the human gastrointestinal microbiome, focusing on the theory and evidence for its role in the development of IgE-mediated food allergy and other allergic diseases.

Indexed as

ChildFood HypersensitivityGastrointestinal TractHumansImmunoglobulin EMicrobiotaImmunoglobulin EAllergic diseaseAllergic rhinitisAsthmaCommensal floraEczemaFood allergyGut microbiotaMicrobiome

Identifiers

PMID26456445
PMCPMC4721650
OpenAlexW2121699387

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.