ArticleThe Journal of physiology2016
Late gestational hypoxia and a postnatal high salt diet programs endothelial dysfunction and arterial stiffness in adult mouse offspring.
Article in The Journal of physiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 36 citations in OpenAlex.
- Understanding physiological adaptations of pregnancy to the chronic hypoxia of high altitude to inform obstetrical and neonatal care.Physiological reviews · 2026Review
- Cardiovascular Consequences of Late-Gestational Hypoxia in Adult Female Rat Offspring and the Effects of Maternal Ergothioneine Treatment.Physiological research · 2026Article
- Effects of a postnatal high-salt diet on cardiac function in offspring from hypoxic pregnancies.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2025Article
- Perinatal Exposure of Dams to a High Salt Diet Impaired Vascular Function and Elevated Biomarkers of Inflammation in the Offspring.Clinical Medicine Insights. Cardiology · 2025Article
- Evidence for hypoxia-induced dysregulated cholesterol homeostasis in preeclampsia: Insights into the mechanisms from human placental cells and tissues.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2024Article
- Vascular nitrosative stress in hypertension induced by fetal undernutrition in rats.Journal of physiology and biochemistry · 2023Article
- Prenatal Hypoxia Affects Foetal Cardiovascular Regulatory Mechanisms in a Sex- and Circadian-Dependent Manner: A Review.International journal of molecular sciences · 2022Review
- Programming of Vascular Dysfunction by Maternal Stress: Immune System Implications.Frontiers in physiology · 2022Review
- Breath of Life: Heart Disease Link to Developmental Hypoxia.Circulation · 2021Article
- Fetuin-A is a HIF target that safeguards tissue integrity during hypoxic stress.Nature communications · 2021Article
- Impact of prenatal hypoxia on the development and behavior of the rat offspring.Physiological research · 2020Article
- Prenatal hypoxia inhibited propionate-evoked BK channels of mesenteric artery smooth muscle cells in offspring.Journal of cellular and molecular medicine · 2020Article
- The Placental Transcriptome in Late Gestational Hypoxia Resulting in Murine Intrauterine Growth Restriction Parallels Increased Risk of Adult Cardiometabolic Disease.Scientific reports · 2019Article
- Inherited risk plus prenatal insult caused malignant dysfunction in mesenteric arteries in adolescent SHR offspring.PloS one · 2019Article
- Prolonged prenatal hypoxia selectively disrupts collecting duct patterning and postnatal function in male mouse offspring.The Journal of physiology · 2018Article
- Uteroplacental insufficiency temporally exacerbates salt-induced hypertension associated with a reduced natriuretic response in male rat offspring.The Journal of physiology · 2018Article
- Gestational Hypoxia and Developmental Plasticity.Physiological reviews · 2018Review
- Downregulation of L-Type Voltage-Gated CaJournal of the American Heart Association · 2018Article
- Prenatal Hypoxia Induced Dysfunction in Cerebral Arteries of Offspring Rats.Journal of the American Heart Association · 2017Article
- Prenatal hypoxia leads to hypertension, renal renin-angiotensin system activation and exacerbates salt-induced pathology in a sex-specific manner.Scientific reports · 2017Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Gestational hypoxia and high dietary salt intake have both been associated with impaired vascular function in adulthood. Using a mouse model of prenatal hypoxia, we examined whether a chronic high salt diet had an additive effect in promoting vascular dysfunction in offspring. Pregnant CD1 dams were placed in a hypoxic chamber (12% O2) or housed under normal conditions (21% O2) from embryonic day 14.5 until birth. Gestational hypoxia resulted in a reduced body weight for both male and female offspring at birth. This restriction in body weight persisted until weaning, after which the animals underwent catch-up growth. At 10 weeks of age, a subset of offspring was placed on a high salt diet (5% NaCl). Pressurized myography of mesenteric resistance arteries at 12 months of age showed that both male and female offspring exposed to maternal hypoxia had significantly impaired endothelial function, as demonstrated by impaired vasodilatation to ACh but not sodium nitroprusside. Endothelial dysfunction caused by prenatal hypoxia was not exacerbated by postnatal consumption of a high salt diet. Prenatal hypoxia increased microvascular stiffness in male offspring. The combination of prenatal hypoxia and a postnatal high salt diet caused a leftward shift in the stress-strain relationship in both sexes. Histopathological analysis of aortic sections revealed a loss of elastin integrity and increased collagen, consistent with increased vascular stiffness. These results demonstrate that prenatal hypoxia programs endothelial dysfunction in both sexes. A chronic high salt diet in postnatal life had an additive deleterious effect on vascular mechanics and structural characteristics in both sexes.
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