ArticleClinical and experimental nephrology2016
Clinical manifestations of Henoch-Schönlein purpura nephritis and IgA nephropathy: comparative analysis of data from the Japan Renal Biopsy Registry (J-RBR).
Article in Clinical and experimental nephrology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
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42 citing papers in PubMed, 53 citations in OpenAlex.
- Clinical, laboratory, and pathological correlates of crescent formation in biopsy-proven pediatric IgA vasculitis nephritis.Pediatric nephrology (Berlin, Germany) · 2026Article
- Proteinuria reduction as a surrogate endpoint for clinical study of IgA nephropathy in Japanese patients: data from the J-CKD-DB-Ex.Clinical and experimental nephrology · 2026Observational
- Clinical characteristics and renal risk stratification of mixed-type IgA vasculitis: a large-volume study.Frontiers in immunology · 2026Article
- Optimal drug treatment for children with IgA vasculitis nephritis: a systematic review and network meta-analysis.Translational pediatrics · 2025Article
- Risk factors of adverse pregnancy outcomes in patients with immunoglobulin A nephropathy.Scientific reports · 2025Article
- Aetiology of acute/subacute nephritic syndrome: results from kidney biopsy registries in Japan and Europe.BMC nephrology · 2025Article
- A case of de novo glomerulonephritis following COVID-19 in a patient with preexistent IgA vasculitis.CEN case reports · 2025Article
- Is Childhood IgA Nephropathy Different From Adult IgA Nephropathy? A Narrative Review.Canadian journal of kidney health and disease · 2025Review
- Modern biomarkers in IgA vasculitis with nephritis in children.Central-European journal of immunology · 2025Review
- Effect of tonsillectomy combined with steroid pulse therapy upon IgA nephropathy depending on proteinuria status at diagnosis: a nationwide multicenter cohort study in Japan.Clinical and experimental nephrology · 2024Article
- Childhood-onset IgA nephropathy: is long-term recovery possible?Pediatric nephrology (Berlin, Germany) · 2024Article
- Erythrocyte Glutathione S-Transferase Activity as a Sensitive Marker of Kidney Function Impairment in Children with IgA Vasculitis.International journal of molecular sciences · 2024Article
- Clinical prediction model for progression from henoch-schönlein purpura to nephritis in pediatric patients.American journal of translational research · 2024Article
- Immunoglobulin A vasculitis nephritis: Current understanding of pathogenesis and treatment.World journal of nephrology · 2023Review
- Comparative study on clinicopathological features and prognosis of IgA vasculitis nephritis and IgA nephropathy in children.BMC pediatrics · 2023Article
- Diagnosis and treatment of IgA nephropathy and IgA vasculitis nephritis in Chinese children.Pediatric nephrology (Berlin, Germany) · 2023Review
- ASSOCIATION BETWEEN HIGH MOBILITY GROUP BOX 1 PROTEIN GENE (rs41369348) POLYMORPHISM AND IMMUNOGLOBULIN A VASCULITIS IN CHILDREN.Acta clinica Croatica · 2023Article
- Towards better indications for kidney biopsy in adult IgA vasculitis: a clinical-laboratory and pathology correlation study.Journal of nephrology · 2023Article
- COVID-19 mRNA vaccination is associated with IgA nephropathy: an analysis of the Japanese adverse drug event report database.Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques · 2023Article
- Comparison of clinical, pathological and long-term renal outcomes of children with Henoch-Schonlein purpura nephritis and IgA nephropathy.International urology and nephrology · 2022Article
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6 authors at 6 institutions in 1 country.
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Abstract
backgroundThe clinical presentation of Henoch-Schönlein purpura nephritis (HSPN) has not been thoroughly investigated among patients of different ages. We therefore compared the features of HSPN and IgA nephropathy (IgAN) based on data from the Japan Renal Biopsy Registry (J-RBR).
methodsThis cross-sectional study analyzed data from patients who were registered in the J-RBR between 2007 and 2012. Clinico-pathological findings at diagnosis were compared among children (aged ≤18 years), adult (aged 19-64 years) and elderly (aged ≥65 years) patients with HSPN (n = 513) and IgAN (n = 5679).
resultsThe age at diagnosis considerably differed between HSPN and IgAN; HSPN peaked at 1-19 and at 60-69 years, whereas IgAN peaked at 30-39 years. The clinical features were significantly more severe for HSPN than IgAN, especially proteinuria (children, 1.28 vs. 0.57; adult, 1.95 vs. 1.05; elderly patients, 2.71 vs. 1.64 g/day), and low albumin levels (children, 3.72 vs. 4.13; adults, 3.62 vs. 3.99; elderly patients, 3.07 vs. 3.57 g/dL). The rate (%) of histologically classified endocapillary proliferative or crescentic glomerulonephritis was higher in patients with HSPN than with IgAN. Multiple regression analysis revealed that low albumin level and high BP were independent factors associated with decreased estimated glomerular filtration rates in adult and elderly patients with HSPN.
conclusionsAge at HSPN diagnosis was bimodally distributed, and the clinical features of HSPN were more severe than those of IgAN across all age groups.
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