Evidence map›Paper›PMID 26456318›Full record

ArticleJournal of the American Geriatrics Society2015

Using a Clinical Surveillance System to Detect Drug-Associated Hypoglycemia in Nursing Home Residents.

Colleen M Culley, Subashan Perera, Zachary A Marcum, Sandra L Kane-Gill, Steven M Handler

Open access · greenAbstract read
In one paragraph

Article in Journal of the American Geriatrics Society, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 6 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Colleen M CulleyDepartment of Pharmacy and Therapeutics, School of Pharmacy, University of Pittsburgh, Pittsburgh, Pennsylvania.
Subashan PereraDivision of Geriatric Medicine, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania.
Zachary A MarcumDepartment of Pharmacy, School of Pharmacy, University of Washington, Seattle, Washington.
Sandra L Kane-GillDepartment of Pharmacy and Therapeutics, School of Pharmacy, University of Pittsburgh, Pittsburgh, Pennsylvania.
Steven M HandlerDepartment of Biomedical Informatics, University of Pittsburgh, Pittsburgh, Pennsylvania.
University of Pittsburgh · USUniversity of Washington · US

Funding

UNIVERSITY OF PITTSBURGH CLINICAL AND TRANSLATIONAL SCIENCE INSTITUTE: BPCAUL1RR024153 · NCRR · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI REIS, STEVEN E · 2006 to 2011
$73.9M
University of Pittsburgh Clinical and Translational Science InstituteUL1TR000005 · NCATS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI REIS, STEVEN E · 2012 to 2015
$50.8M
VARIABILITY, STABILITY & SMOOTHNESS OF WALKINGP30AG024827 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI JENNIFER S BRACH · 2004 to 2026
$28.6M
Pitt Integrated Clinical and Geroscience Research Training ProgramT32AG021885 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Aditi U Gurkar · 2003 to 2026
$6.7M
Enhancing the Detection and Management of Adverse Drug Events in the Nursing HomeR01HS018721 · AHRQ · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI HANDLER, STEVEN MARK · 2010 to 2013
$2.0M
Longitudinal Impact of CNS Polypharmacy on Geriatric SyndromesR01AG027017 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI HANLON, JOSEPH T · 2006 to 2012
$801k
UPITT Program for Pharmaceutical Outcomes Research in AgingK07AG033174 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI HANLON, JOSEPH T · 2009 to 2013
$461k
AHRQ HHS R01 HS018721NCATS NIH HHS UL1 TR000005NCRR NIH HHS UL1 RR024153NIA NIH HHS K07 AG033174NIA NIH HHS P30 AG024827NIA NIH HHS R01 AG027017NIA NIH HHS T32 AG021885
6 · The paper itself

Abstract

objectivesTo determine whether a clinical surveillance system could be used to detect drug-associated hypoglycemia events and determine their incidence in nursing home (NH) residents.

designRetrospective cohort.

settingFour NHs in western Pennsylvania.

participantsAny resident of the four NHs who had a computer-generated alert detecting potential drug-associated hypoglycemia over a 6-month period were included. MEASUREMENTS: Descriptive statistics were used to summarize all variables, including the frequency and distribution of alert type according to glucose threshold. Analyses were conducted according to numbers of alerts and residents. The medications associated with the drug-associated hypoglycemia alerts were identified, and frequency of their inclusion in alerts was calculated. Additional calculations included time to drug-associated hypoglycemic event alert from date of admission and frequency of events associated with postacute, short-stay (≤35 days) admissions.

resultsSeven hundred seventy-two alerts involving 141 residents were detected. Ninety (63.8%) residents had a glucose level of 55 mg/dL or less, and 42 (29.8%) had a glucose level of 40 mg/dL or less. Insulin orders were associated with 762 (98.7%) alerts. Overall incidence of drug-associated hypoglycemia events was 9.5 per 1,000 resident-days.

conclusionHypoglycemia can be detected using a clinical surveillance system. This evaluation found a high incidence of drug-associated hypoglycemia in a general NH population. Future studies are needed to determine the potential benefits of use of a surveillance system in real-time detection and management of hypoglycemia in NHs.

Indexed as

HypoglycemiaAdverse Drug Reaction Reporting SystemsAgedAged, 80 and overBlood GlucoseFemaleGeriatric AssessmentHomes for the AgedHumansHypoglycemic AgentsIncidenceInsulinMaleNursing HomesPennsylvaniaPopulation SurveillanceBlood GlucoseHypoglycemic AgentsInsulinadverse drug event detectionclinical surveillancehypoglycemianursing home

Identifiers

PMID26456318
PMCPMC4778416
OpenAlexW1943240014

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.