ArticleJournal of neural transmission (Vienna, Austria : 1996)2016
Association between ACE polymorphism, cognitive phenotype and APOE E4 allele in a Tunisian population with Alzheimer disease.
Article in Journal of neural transmission (Vienna, Austria : 1996), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 16 citations in OpenAlex.
- Angiotensin-converting enzyme polymorphisms AND Alzheimer's disease susceptibility: An updated meta-analysis.PloS one · 2021Pooled it
- Association between angiotensin-converting enzyme gene insertion/deletion polymorphism and cognition impairment in patients with schizophrenia.Psychopharmacology · 2024Article
- Missense mutation of angiotensin converting enzyme gene in an Alzheimer's disease patient: a case report.Frontiers in neuroscience · 2024Article
- Association of Apolipoprotein E Gene Polymorphism with Type 2 Diabetic Nephropathy in the Southern Chinese Population.International journal of general medicine · 2023Article
- Association of a common genetic variant (insertion/deletion) in ACE gene with prostate cancer susceptibility in a Tunisian population.Journal of clinical laboratory analysis · 2022Article
- Association ofNeuropsychiatric disease and treatment · 2020Article
- Analysis of SLCO1B1 and APOE genetic polymorphisms in a large ethnic Hakka population in southern China.Journal of clinical laboratory analysis · 2018Article
- Association of APOE Gene Polymorphisms with Cerebral Infarction in the Chinese Population.Medical science monitor : international medical journal of experimental and clinical research · 2018Article
- Apolipoprotein E polymorphism and the risk of aneurysmal subarachnoid hemorrhage in a South Indian population.Cellular & molecular biology letters · 2017Article
- Association between an angiotensin-converting enzyme gene polymorphism and Alzheimer's disease in a Tunisian population.Annals of general psychiatry · 2017Article
- Polymorphisms of apolipoprotein E and aneurysmal subarachnoid haemorrhage: A meta-analysis.Meta gene · 2016Review
- Association of Increased Serum ACE Activity with Logical Memory Ability in Type 2 Diabetic Patients with Mild Cognitive Impairment.Frontiers in behavioral neuroscience · 2016Article
- Analysis of apolipoprotein E genetic polymorphism in a large ethnic Hakka population in southern China.Genetics and molecular biologyArticle
Corrections and comments
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Authors and funding
12 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Angiotensin-converting enzyme (ACE) has shown altered activity in patients with neurological diseases. An insertion/deletion (I/D) polymorphism of the ACE gene encoding angiotensin-converting enzyme has been reported to be associated with the risk for Alzheimer's disease (AD), and is generally considered to be a disorder primarily affecting memory. We conducted a case-control study in a sample composed of 85 sporadic AD patients and 90 age- and sex-matched controls to investigate the possible effect of the polymorphism and cognitive profile. Our data revealed an association between the ACE polymorphism and AD risk. There was a significant difference in the ACE allele or genotype frequencies between cases and controls. The D/D genotype showed an increased risk for AD and in the amnestic group and the effect was independent on ApoE genotypes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.