ArticleNature communications2015
Migration of germline progenitor cells is directed by sphingosine-1-phosphate signalling in a basal chordate.
Article in Nature communications, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
20 citing papers in PubMed, 40 citations in OpenAlex.
- Harnessing the Power ofCold Spring Harbor perspectives in biology · 2026Review
- The journey of a generation: advances and promises in the study of primordial germ cell migration.Development (Cambridge, England) · 2024Article
- Astrocyte growth is driven by the Tre1/S1pr1 phospholipid-binding G protein-coupled receptor.Neuron · 2024Article
- Increased collective migration correlates with germline stem cell competition in a basal chordate.PloS one · 2023Article
- Effects of FTY720 on Neural Cell Behavior in Two and Three-Dimensional Culture and in Compression Spinal Cord Injury.Cellular and molecular bioengineering · 2022Article
- Noninvasive Intravascular Microtransfusion in Colonial Tunicates.Methods in molecular biology (Clifton, N.J.) · 2022Article
- Article
- Comparative transcriptomic analysis reveals gene regulation mediated by caspase activity in a chordate organism.BMC molecular and cell biology · 2021Article
- Chromosomal-Level Genome Assembly of the Painted Sea Urchin Lytechinus pictus: A Genetically Enabled Model System for Cell Biology and Embryonic Development.Genome biology and evolution · 2021Article
- Early patterning of ABCB, ABCC, and ABCG transporters establishes unique territories of small molecule transport in embryonic mesoderm and endoderm.Developmental biology · 2021Article
- Vascular Aging in the Invertebrate Chordate,Frontiers in molecular biosciences · 2021Article
- Integrin-alpha-6+ Candidate stem cells are responsible for whole body regeneration in the invertebrate chordate Botrylloides diegensis.Nature communications · 2020Article
- Evidence that ABC transporter-mediated autocrine export of an eicosanoid signaling molecule enhances germ cell chemotaxis in the colonial tunicateDevelopment (Cambridge, England) · 2020Article
- Progenitor targeting by adult stem cells in Ciona homeostasis, injury, and regeneration.Developmental biology · 2019Article
- Convergent Acquisition of Nonembryonic Development in Styelid Ascidians.Molecular biology and evolution · 2018Article
- Domain-specific control of germ cell polarity and migration by multifunction Tre1 GPCR.The Journal of cell biology · 2017Article
- Finding their way: themes in germ cell migration.Current opinion in cell biology · 2016Review
- Transcriptome dynamics in the asexual cycle of the chordate Botryllus schlosseri.BMC genomics · 2016Article
- Effects of FTY720 (Fingolimod) on Proliferation, Differentiation, and Migration of Brain-Derived Neural Stem Cells.Stem cells international · 2016Article
- Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
The colonial ascidian Botryllus schlosseri continuously regenerates entire bodies in an asexual budding process. The germ line of the newly developing bodies is derived from migrating germ cell precursors, but the signals governing this homing process are unknown. Here we show that germ cell precursors can be prospectively isolated based on expression of aldehyde dehydrogenase and integrin alpha-6, and that these cells express germ cell markers such as vasa, pumilio and piwi, as well as sphingosine-1-phosphate receptor. In vitro, sphingosine-1-phosphate (S1P) stimulates migration of germ cells, which depends on integrin alpha-6 activity. In vivo, S1P signalling is essential for homing of germ cells to newly developing bodies. S1P is generated by sphingosine kinase in the developing germ cell niche and degraded by lipid phosphate phosphatase in somatic tissues. These results demonstrate a previously unknown role of the S1P signalling pathway in germ cell migration in the ascidian Botryllus schlosseri.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.