ArticleNature communications2015
Theta oscillations regulate the speed of locomotion via a hippocampus to lateral septum pathway.
Article in Nature communications, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 121 papers.
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Who cites it
121 citing papers in PubMed.
- Cannabinoid receptor-mediated disruption of sensory gating and neural oscillations: A translational study in rats and humans.Neuropharmacology · 2018Trial
- Methods for measuring neural activity during voluntary wheel running.Journal of neuroscience methods · 2026Article
- Tryptamine from wake-active monoaminergic neurons regulates sleep homeostasis.Nature neuroscience · 2026Article
- Multimodal classification of neurons in the lateral septum.bioRxiv : the preprint server for biology · 2026Article
- Article
- Balancing acts: lateral hypothalamic circuits coordinating feeding, anxiety, and social interactions.Reviews in endocrine & metabolic disorders · 2026Review
- Dorsal CA1 projections to nucleus accumbens and lateral septum differentially regulate social and locomotor behavior.Cerebral cortex (New York, N.Y. : 1991) · 2026Article
- The crossroads between osteosarcopenia and intrinsic capacity-a narrative review.The journals of gerontology. Series A, Biological sciences and medical sciences · 2026Review
- Bidirectional regulation of social memory by two distinct types of GABAergic neurons in the lateral septum.Nature communications · 2026Article
- Hippocampal-Prelimbic Coupling During Context-Dependent Extinction Retrieval in Rats.Hippocampus · 2026Article
- Dysfunction of the rostral lateral septum GABAergic neurons induces mania-like behavior in male mice.Translational psychiatry · 2025Article
- The medial septum-hippocampus-lateral septum circuitry in spatial memory: linking healthy function to early Alzheimer's disease and translational opportunities.Translational neurodegeneration · 2025Review
- Disruption of theta-timescale spiking impairs learning but spares hippocampal replay.bioRxiv : the preprint server for biology · 2025Article
- Altered patterning of neural activity in a neuropathology.Scientific reports · 2025Article
- Pedunculopontine-stimulation obstructs hippocampal theta rhythm and halts movement.Scientific reports · 2025Article
- Anterior Cingulate Cortex Contributes to the Hyperlocomotion under Nitrogen Narcosis.Neuroscience bulletin · 2025Article
- Ultrasound-Induced Synchronized Neural Activities at 40 Hz and 200 Hz Entrained Corresponded Oscillations and Improve Alzheimer's Disease Memory.CNS neuroscience & therapeutics · 2025Article
- The dorsal and ventral hippocampus contribute differentially to spatial working memory and spatial coding in the prefrontal cortex.PLoS biology · 2025Article
- Medial septal theta stimulation enhances spatial working memory performance in rats.Learning & memory (Cold Spring Harbor, N.Y.) · 2025Article
- Impairment of theta oscillations in the hippocampal CA1 region may mediate age-dependent movement alternations in the 5xFAD mouse model of Alzheimer's disease.Scientific reports · 2025Article
61 more citing papers are in PubMed but not listed here.
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hippocampal theta oscillations support encoding of an animal's position during spatial navigation, yet longstanding questions about their impact on locomotion remain unanswered. Combining optogenetic control of hippocampal theta oscillations with electrophysiological recordings in mice, we show that hippocampal theta oscillations regulate locomotion. In particular, we demonstrate that their regularity underlies more stable and slower running speeds during exploration. More regular theta oscillations are accompanied by more regular theta-rhythmic spiking output of pyramidal cells. Theta oscillations are coordinated between the hippocampus and its main subcortical output, the lateral septum (LS). Chemo- or optogenetic inhibition of this pathway reveals its necessity for the hippocampal regulation of running speed. Moreover, theta-rhythmic stimulation of LS projections to the lateral hypothalamus replicates the reduction of running speed induced by more regular hippocampal theta oscillations. These results suggest that changes in hippocampal theta synchronization are translated into rapid adjustment of running speed via the LS.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.