ArticleProceedings of the National Academy of Sciences of the United States of America1989
Cellular differentiation in the emerging fetal rat small intestinal epithelium: mosaic patterns of gene expression.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1989. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 80 citations in OpenAlex.
- Molecular analysis and intestinal expression of SAR1 genes and proteins in Anderson's disease (Chylomicron retention disease).Orphanet journal of rare diseases · 2011Article
- Localization, function and regulation of the two intestinal fatty acid-binding protein types.Histochemistry and cell biology · 2009Article
- Proteomic changes during intestinal cell maturation in vivo.Journal of proteomics · 2008Article
- Role of peroxisome-proliferator-activated receptor beta/delta (PPARbeta/delta) in gastrointestinal tract function and disease.Clinical science (London, England : 1979) · 2008Review
- Functions of p21 and p27 in the regenerating epithelial linings of the mouse small and large intestine.Cancer biology & therapy · 2008Article
- Intestinal M cells: the fallible sentinels?World journal of gastroenterology · 2007Review
- Protein tyrosine kinase 6 negatively regulates growth and promotes enterocyte differentiation in the small intestine.Molecular and cellular biology · 2006Article
- Improving M cell mediated transport across mucosal barriers: do certain bacteria hold the keys?Immunology · 2004Review
- Transforming growth factor-beta mediates intestinal healing and susceptibility to injury in vitro and in vivo through epithelial cells.The American journal of pathology · 2003Article
- Review
- Expression of intrinsic factor in rat and murine gastric mucosal cell lineages is modified by inflammation.The American journal of pathology · 2000Article
- Variegated expression of a globin transgene correlates with chromatin accessibility but not methylation status.Nucleic acids research · 1996Article
- Review
- Position-dependent variegation of globin transgene expression in mice.Proceedings of the National Academy of Sciences of the United States of America · 1995Article
- Cell-specific and spatio-temporal expression of intestinal fatty acid-binding protein gene during amphibian metamorphosis.Roux's archives of developmental biology : the official organ of the EDBO · 1994Article
- Cellular epigenetics: effects of passage history on competence of cells for "spontaneous" transformation.Proceedings of the National Academy of Sciences of the United States of America · 1993Article
- Mosaic expression of a tyrosinase fusion gene in albino mice yields a heritable striped coat color pattern in transgenic homozygotes.Proceedings of the National Academy of Sciences of the United States of America · 1991Article
- Epithelial cell differentiation in normal and transgenic mouse intestinal isografts.The Journal of cell biology · 1991Article
- Developmental regulation of mammary-derived growth inhibitor expression in bovine mammary tissue.The Journal of cell biology · 1990Article
- Mapping enteroendocrine cell populations in transgenic mice reveals an unexpected degree of complexity in cellular differentiation within the gastrointestinal tract.The Journal of cell biology · 1990Article
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
We have examined the pattern of differentiation of the small intestinal epithelium in fetal rats during the 17th through 21st days of gestation. Five genes expressed in late fetal, neonatal, and adult enterocytes were used as markers of differentiation. They encode three homologous small cytoplasmic hydrophobic ligand binding proteins--liver fatty acid binding protein (L-FABP), intestinal fatty acid binding protein (I-FABP), and cellular retinol binding protein II (CRBP II)--and two apolipoproteins--apoAI and apoAIV. RNA blot hybridization studies indicated that gradients in mRNA concentration from the proximal small intestine to colon appear coincident with the initiation of rapid epithelial cell proliferation and villus formation (days 17-19 of the 22-day gestation period). Immunocytochemical studies disclosed a remarkably heterogeneous pattern of cell-specific expression of the three hydrophobic ligand binding proteins that was not apparent with either apoAIV or apoAI. This "mosaic" staining pattern was observed in morphologically similar cells occupying identical topographic positions along nascent villi in 17- to 18-day fetuses. The onset and resolution of this mosaicism varies between I-FABP, L-FABP, and CRBP II in the proximal small bowel, although it completely resolves by the first postnatal day. The distal small intestine exhibits a developmental delay of 1-2 days in the appearance of this heterogeneous pattern of initial gene expression. Double-label immunofluorescent analyses using L-FABP and I-FABP antibodies indicated that on the 18th day of gestation the proximal small intestinal columnar epithelium contains several populations of enterocytes expressing neither, one, or both proteins. The potential significance of this mosaic pattern of intestinal epithelial differentiation is discussed in light of recent studies with transgenic and chimeric mice.
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