Evidence map›Paper›PMID 26455441›Full record

ArticleThe Analyst2015

Templated polymers enable selective capture and release of lysophosphatidic acid in human plasma via optimization of non-covalent binding to functional monomers.

Jialu Wang, Martha Sibrian-Vazquez, Jorge O Escobedo, Lei Wang, Yu-Hsuan Chu, Richard G Moore, Robert M Strongin

Abstract read
In one paragraph

Article in The Analyst, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 97% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 3 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Jialu WangDepartment of Chemistry, Portland State University, Portland, OR 97201, USA. strongin@pdx.edu.
Martha Sibrian-VazquezDepartment of Chemistry, Portland State University, Portland, OR 97201, USA. strongin@pdx.edu.
Jorge O EscobedoDepartment of Chemistry, Portland State University, Portland, OR 97201, USA. strongin@pdx.edu.
Lei WangDepartment of Chemistry, Portland State University, Portland, OR 97201, USA. strongin@pdx.edu.
Yu-Hsuan ChuDepartment of Chemistry, Portland State University, Portland, OR 97201, USA. strongin@pdx.edu.
Richard G MooreWomen and Infants Hospital, Brown University, Providence, RI 02905, USA.
Robert M StronginDepartment of Chemistry, Portland State University, Portland, OR 97201, USA. strongin@pdx.edu.
Portland State University · USBrown University · US

Funding

Development of an Assay for the Early Detection of Ovarian CancerR01CA136491 · NCI · WOMEN AND INFANTS HOSPITAL-RHODE ISLAND · PI MOORE, RICHARD G. · 2009 to 2013
$1.9M
NCI NIH HHS R01 CA136491NCI NIH HHS R01CA136491
6 · The paper itself

Abstract

The first solid phase extraction materials for selective lysophosphatidic acid (LPA) enrichment from human plasma are described. Molecularly imprinted polymers were designed, synthesized and evaluated as cartridge fillings. They enabled a relatively rapid and simple extraction protocol for LPA without any need for multiple liquid-liquid extraction steps. The five major subspecies of lysophosphatidic acid are readily separated from all other native plasma phospholipids, including those well-known to interfere with LPA quantitation, such as phosphatidylcholine and lysophosphatidylcholine. Outstanding LPA purity is obtained via these solid phase materials in a tandem extraction setup.

Indexed as

Chromatography, High Pressure LiquidHumansLiquid-Liquid ExtractionLysophospholipidsMolecular ImprintingPolymersSolid Phase ExtractionSpectrometry, Mass, Electrospray Ionizationlysophosphatidic acidLysophospholipidsPolymers

Identifiers

PMID26455441
PMCPMC4642816
OpenAlexW1771695123

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.