Evidence map›Paper›PMID 26455320›Full record

ArticleOncogene2016

Tumour-suppression function of KLF12 through regulation of anoikis.

N Godin-Heymann, S Brabetz, M M Murillo, M Saponaro, C R Santos, A Lobley, P East, P Chakravarty, N Matthews, G Kelly and 3 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Oncogene, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
0.9field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 53 citations in OpenAlex.

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  16. KLF12 Regulates Mouse NK Cell Proliferation.Journal of immunology (Baltimore, Md. : 1950) · 2019
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  17. Article
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  19. MicroRNA-137 reduces stemness features of pancreatic cancer cells by targeting KLF12.Journal of experimental & clinical cancer research : CR · 2019
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  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 1 institution in 1 country.

N Godin-HeymannSignal Transduction, Cancer Research UK London Research Institute, London, UK.
S BrabetzSignal Transduction, Cancer Research UK London Research Institute, London, UK.
M M MurilloSignal Transduction, Cancer Research UK London Research Institute, London, UK.
M SaponaroMechanisms of Gene Transcription Laboratory, Cancer Research UK London Research Institute, Clare Hall Laboratories, Hertfordshire, UK.
C R SantosTranslational Cancer Therapeutics, Cancer Research UK London Research Institute, London, UK.
A LobleyBioinformatics and Biostatistics Laboratories, Cancer Research UK London Research Institute, London, UK.
P EastBioinformatics and Biostatistics Laboratories, Cancer Research UK London Research Institute, London, UK.
P ChakravartyBioinformatics and Biostatistics Laboratories, Cancer Research UK London Research Institute, London, UK.
N MatthewsAdvanced Sequencing Facility, Cancer Research UK London Research Institute, London, UK.
G KellyBioinformatics and Biostatistics Laboratories, Cancer Research UK London Research Institute, London, UK.
S JordanSignal Transduction, Cancer Research UK London Research Institute, London, UK.
E CastellanoSignal Transduction, Cancer Research UK London Research Institute, London, UK.
J DownwardSignal Transduction, Cancer Research UK London Research Institute, London, UK.
Cancer Research UK · GB

Funding

Cancer Research UK 15680
6 · The paper itself

Abstract

Suppression of detachment-induced cell death, known as anoikis, is an essential step for cancer metastasis to occur. We report here that expression of KLF12, a member of the Kruppel-like family of transcription factors, is downregulated in lung cancer cell lines that have been selected to grow in the absence of cell adhesion. Knockdown of KLF12 in parental cells results in decreased apoptosis following cell detachment from matrix. KLF12 regulates anoikis by promoting the cell cycle transition through S phase and therefore cell proliferation. Reduced expression levels of KLF12 results in increased ability of lung cancer cells to form tumours in vivo and is associated with poorer survival in lung cancer patients. We therefore identify KLF12 as a novel metastasis-suppressor gene whose loss of function is associated with anoikis resistance through control of the cell cycle.

Indexed as

Gene Expression Regulation, NeoplasticA549 CellsAnimalsAnoikisCell CycleCell Line, TumorCell ProliferationDown-RegulationFlow CytometryHumansKruppel-Like Transcription FactorsLung NeoplasmsMice, Inbred NODMice, KnockoutMice, SCIDNeoplasm MetastasisKLF12 protein, humanKruppel-Like Transcription FactorsTumor Suppressor Proteins

Identifiers

PMID26455320
PMCPMC4929484
OpenAlexW2426832038

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.