ArticleCurrent biology : CB2015
Propagation of Homeostatic Sleep Signals by Segregated Synaptic Microcircuits of the Drosophila Mushroom Body.
Article in Current biology : CB, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 93 papers.
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Who cites it
93 citing papers in PubMed.
- Local autophagy impairment triggers brain-wide presynaptic remodeling and resilience.The EMBO journal · 2026Article
- Octopamine regulates neural circuits in the mushroom body and central complex, influencing sleep and arousal.iScience · 2026Article
- Sleep facilitates pattern separation through SK channel-mediated sparse coding.Current biology : CB · 2026Article
- The use ofFrontiers in cell and developmental biology · 2026Review
- Sleep rescues age-associated loss of glial engulfment.PLoS genetics · 2026Article
- Early life sleep is associated with longevity inbioRxiv : the preprint server for biology · 2025Article
- A switch in arousal circuit architecture shapes sleep across the lifespan.bioRxiv : the preprint server for biology · 2025Article
- Neurobiology of mitochondrial dynamics in sleep.The Journal of physiology · 2025Review
- Octopamine signaling regulates the intracellular pattern of the presynaptic active zone scaffold within Drosophila mushroom body neurons.PLoS biology · 2025Article
- Sleep drive, not total sleep amount, increases seizure risk.Nature communications · 2025Article
- Insight into molecular and neural mechanisms of general anesthesia from the invertebrate modelZoological research · 2025Review
- Alcohol induces long-lasting sleep deficits in Drosophila via subsets of cholinergic neurons.Current biology : CB · 2025Article
- Enhanced memory despite severe sleep loss in Drosophila insomniac mutants.PLoS biology · 2025Article
- Activity Monitoring for Analysis of Sleep inCold Spring Harbor protocols · 2024Article
- Fly into tranquility: GABA's role in Drosophila sleep.Current opinion in insect science · 2024Review
- The caloric value of food intake structurally adjusts a neuronal mushroom body circuit mediating olfactory learning inLearning & memory (Cold Spring Harbor, N.Y.) · 2024Article
- An integrative sensor of body states: how the mushroom body modulates behavior depending on physiological context.Learning & memory (Cold Spring Harbor, N.Y.) · 2024Review
- Skewing information flow through pre- and postsynaptic plasticity in the mushroom bodies ofLearning & memory (Cold Spring Harbor, N.Y.) · 2024Review
- Article
- Alcohol sensitivity and tolerance encoding in sleep regulatory circadian neurons in Drosophila.Addiction biology · 2023Article
33 more citing papers are in PubMed but not listed here.
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Authors and funding
7 authors.
Funding
Abstract
The Drosophila mushroom body (MB) is a key associative memory center that has also been implicated in the control of sleep. However, the identity of MB neurons underlying homeostatic sleep regulation, as well as the types of sleep signals generated by specific classes of MB neurons, has remained poorly understood. We recently identified two MB output neuron (MBON) classes whose axons convey sleep control signals from the MB to converge in the same downstream target region: a cholinergic sleep-promoting MBON class and a glutamatergic wake-promoting MBON class. Here, we deploy a combination of neurogenetic, behavioral, and physiological approaches to identify and mechanistically dissect sleep-controlling circuits of the MB. Our studies reveal the existence of two segregated excitatory synaptic microcircuits that propagate homeostatic sleep information from different populations of intrinsic MB "Kenyon cells" (KCs) to specific sleep-regulating MBONs: sleep-promoting KCs increase sleep by preferentially activating the cholinergic MBONs, while wake-promoting KCs decrease sleep by preferentially activating the glutamatergic MBONs. Importantly, activity of the sleep-promoting MB microcircuit is increased by sleep deprivation and is necessary for homeostatic rebound sleep (i.e., the increased sleep that occurs after, and in compensation for, sleep lost during deprivation). These studies reveal for the first time specific functional connections between subsets of KCs and particular MBONs and establish the identity of synaptic microcircuits underlying transmission of homeostatic sleep signals in the MB.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.