Evidence map›Paper›PMID 26454822›Full record

ArticleMolecular neurobiology2016

Serum Levels of Brain-Derived Neurotrophic Factor Are Associated with Diabetes Risk, Complications, and Obesity: a Cohort Study from Chinese Patients with Type 2 Diabetes.

Bo Li, Ning Lang, Zhi-Feng Cheng

Abstract read
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In one paragraph

Article in Molecular neurobiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
50citing papers in PubMed, 5 pooled it
3.2field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

50 citing papers in PubMed, 5 syntheses or guidelines pooled it, 91 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Bo LiDepartment of Endocrinology and Metabolic Disease, The Fourth Affiliated Hospital of Harbin Medical University, No. 37, Yiyuan Street, Harbin, 150001, People's Republic of China.
Ning LangDepartment of Endocrinology and Metabolic Disease, The Fourth Affiliated Hospital of Harbin Medical University, No. 37, Yiyuan Street, Harbin, 150001, People's Republic of China.
Zhi-Feng ChengDepartment of Endocrinology and Metabolic Disease, The Fourth Affiliated Hospital of Harbin Medical University, No. 37, Yiyuan Street, Harbin, 150001, People's Republic of China. wcgczf@vip.sina.com.
Fourth Affiliated Hospital of Harbin Medical University · CNHarbin Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Brain-derived neurotrophic factor (BDNF) is associated with systemic inflammatory conditions, such as diabetes. The aim of this study was to assess the serum BDNF levels in Chinese patients with type 2 diabetes (T2DM). From the outpatient clinic at the endocrinology department of our hospital, all patients with long-standing T2DM were recruited for this study between August 2014 and December 2014. Serum levels of BDNF were assayed with solid-phase sandwich ELISA, and the demographical and clinical data were evaluated on admission. Median serum BDNF levels were significantly lower in patients with T2DM compared to control subjects (15.9 ng/mL (interquartile range (IQR), 12.6-19.8) VS. 24.6 ng/mL (IQR, 17.2-27.8); P < 0.0001). Serum BDNF levels were inversely correlated with fasting glucose (r = -0.394, P < 0.0001) and duration of illness (r = -0.272, P < 0.0001) in T2DM patients. Based on the receiver operating characteristic (ROC) curve, the optimal cutoff value of serum BDNF levels as an indicator for diagnosis of T2DM was projected to be 23.0 ng/mL, which yielded a sensitivity of 89.0 % and a specificity of 60.9 %, with the area under the curve at 0.794 (95 % confidence interval (CI), 0.747-0.841; P < 0.001). In multivariate logistic regression analysis, after adjusting for other significant factors, BDNF can be seen as an indicator of independent diabetes complications with an odds ratio (OR) of 0.84 (95 % CI, 0.75-0.89; P < 0.001) and obesity with an OR of 0.88 (95 % CI, 0.80-0.92; P < 0.001). Our study suggested that low levels of BDNF accompany impaired glucose metabolism. Importantly, we found that decreased BDNF were correlated with obesity and diabetes complications.

Indexed as

Asian PeopleAgedBrain-Derived Neurotrophic FactorCase-Control StudiesCohort StudiesDiabetes Mellitus, Type 2FemaleHumansMaleMiddle AgedObesityRisk FactorsROC CurveBrain-Derived Neurotrophic FactorBrain-derived neurotrophic factorChineseDiabetes complicationsRiskType 2 diabetes

Identifiers

PMID26454822
OpenAlexW1855907649

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.