ArticleEvolution, medicine, and public health2015
Clinical management of resistance evolution in a bacterial infection: A case study.
Article in Evolution, medicine, and public health, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed, 29 citations in OpenAlex.
- Exploring molecular mechanisms of aminoglycoside resistance in Escherichia coli MG1655 using the antibiotic resistance growth plate.Scientific reports · 2026Article
- Fast hospital discharge rates blur within-hospital 'transmission footprint' in bacterial genomes, as showcased with Staphylococcus aureus.PLoS computational biology · 2026Article
- The evolution of antibiotic resistance in an incurable and ultimately fatal infection: A retrospective case study.Evolution, medicine, and public health · 2023Article
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- Antibiotics can be used to contain drug-resistant bacteria by maintaining sufficiently large sensitive populations.PLoS biology · 2020Article
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- Effect of drug dose and timing of treatment on the emergence of drug resistanceEvolution, medicine, and public health · 2020Article
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- Evolutionary ecology meets the antibiotic crisis: Can we control pathogen adaptation through sequential therapy?Evolution, medicine, and public health · 2019Review
- Why the evolution of vaccine resistance is less of a concern than the evolution of drug resistance.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- An ecosystem framework for understanding and treating disease.Evolution, medicine, and public health · 2018Review
- Why does drug resistance readily evolve but vaccine resistance does not?Proceedings. Biological sciences · 2017Review
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Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We report the case of a patient with a chronic bacterial infection that could not be cured. Drug treatment became progressively less effective due to antibiotic resistance, and the patient died, in effect from overwhelming evolution. Even though the evolution of drug resistance was recognized as a major threat, and the fundamentals of drug resistance evolution are well understood, it was impossible to make evidence-based decisions about the evolutionary risks associated with the various treatment options. We present this case to illustrate the urgent need for translational research in the evolutionary medicine of antibiotic resistance.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.