ArticleSurgery2016
DNA copy amplification and overexpression of SLC12A7 in adrenocortical carcinoma.
Article in Surgery, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it, 14 citations in OpenAlex.
- Meta-analysis of urinary metabolite GWAS studies identifies novel genome-wide significant loci.Scientific reports · 2025Pooled it
- Patient Experience of Adrenocortical Carcinoma: Views from a Patient, His Physician and a Patient Association.Advances in therapy · 2026Article
- Article
- Investigation of psychosocial stress and DNA methylation in genes related to immune response, metabolism, and calcium signaling among African American and White middle-aged adults.Environmental epigenetics · 2026Article
- Prognostic value of RNA methylation-related genes in gastric adenocarcinoma based on bioinformatics.PeerJ · 2024Article
- Article
- SLC12A8 plays a key role in bladder cancer progression and EMT.Open medicine (Warsaw, Poland) · 2021Article
- Prognostic Significance and Tumor Immune Microenvironment Heterogenicity of m5C RNA Methylation Regulators in Triple-Negative Breast Cancer.Frontiers in cell and developmental biology · 2021Article
- Recurrent Amplification of the Osmotic Stress Transcription FactorJournal of the Endocrine Society · 2020Article
- SLC12A7 alters adrenocortical carcinoma cell adhesion properties to promote an aggressive invasive behavior.Cell communication and signaling : CCS · 2018Article
- Difference of molecular alterations in HER2-positive and HER2-negative gastric cancers by whole-genome sequencing analysis.Cancer management and research · 2018Article
- A novel FOXO1-mediated dedifferentiation blocking role for DKK3 in adrenocortical carcinogenesis.BMC cancer · 2017Article
Corrections and comments
- Commented on byDiscussion.2016
Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
Abstract
backgroundOverexpression of Solute carrier family 12 member 7 (SLC12A7) promotes tumor aggressiveness in various cancers. Previous studies have identified the 5p15.33 region, containing the SLC12A7 locus, as being amplified frequently in adrenocortical carcinoma (ACC). Copy number amplifications (CNAs) may alter gene expression levels and occur frequently in ACC; however, SLC12A7 gene amplifications or expression levels have not been studied in ACC.
methodsFifty-five cases of clinically well-characterized ACCs were recruited for this study. Whole-exome sequencing was used to predict CNAs in 19 samples. CNA analysis was performed on an expanded cohort of 26 samples with the use of TaqMan Copy Number Assays. SLC12A7 mRNA expression was analyzed in 32 samples with real-time quantitative polymerase chain reaction and protein expression was assessed by immunohistochemistry. SLC12A7 CNAs and expression patterns were evaluated for correlation with patient and tumor characteristics.
resultsWhole-exome sequencing and TaqMan Copy Number Assays demonstrated SLC12A7 amplifications in 68.4% and 65.4% of ACCs tested, respectively. Furthermore, SLC12A7 copy gains were associated with increased gene expression (P < .05) and non-functional tumors (P < .05). SLC12A7 gene expression levels were increased in ACCs compared with normal adrenal tissue (P < .05).
conclusionSLC12A7 gene amplification and overexpression occurs frequently in ACCs and may represent a novel molecular event associated with ACC.
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Registered trials
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