ArticleJournal of stroke and cerebrovascular diseases : the official journal of National Stroke Association2016
Seizures Following Ischemic Stroke: Frequency of Occurrence and Impact on Outcome in a Long-Term Population-Based Study.
Article in Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 5 of them syntheses that pooled it.
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Who cites it
31 citing papers in PubMed, 5 syntheses or guidelines pooled it.
- Post-stroke seizures in animal models: a systematic review and meta-analysis.Frontiers in neuroscience · 2025Pooled it
- Incidence and risk factors of post-stroke seizures and epilepsy: systematic review and meta-analysis.The Journal of international medical research · 2023Pooled it
- Efficacy of levetiracetam compared with phenytoin in prevention of seizures in brain injured patients: A meta-analysis.Medicine · 2018Pooled it
- Levetiracetam versus phenytoin for seizure prophylaxis in brain injured patients: a systematic review and meta-analysis.International journal of clinical pharmacy · 2017Pooled it
- Association between seizures after ischemic stroke and stroke outcome: A systematic review and meta-analysis.Medicine · 2016Pooled it
- Outcomes of patients with post-stroke epilepsy: A scoping review on quality of life, readmissions, costs, seizure recurrence, and medication adherence.Epilepsia open · 2026Review
- Association of carotid revascularization with epilepsy and seizures in patients with carotid stenosis.Epilepsia · 2026Article
- The incidence and impact of early post-stroke seizures for successful endovascular stroke treatment: an individual patient data level analysis of trials.International journal of surgery (London, England) · 2026Article
- Evaluating the Prevalence of Optimal Neurodevelopmental Outcome at 4.5-Years in Children Previously on Ventricular Assist Device Support.Pediatric transplantation · 2026Article
- The Progress of Poststroke Seizures.Neurochemical research · 2024Review
- Early Epileptic Seizures after Ischemic Stroke: Their Association with Stroke Risk Factors and Stroke Characteristics.Medicina (Kaunas, Lithuania) · 2023Article
- Post-stroke seizures: risk factors and management after ischemic stroke.Acta neurologica Belgica · 2023Article
- Comparative Effectiveness and Safety of Seizure Prophylaxis Among Adults After Acute Ischemic Stroke.Stroke · 2023Article
- Post-stroke seizures, epilepsy, and mortality in a prospective hospital-based study.Frontiers in neurology · 2023Article
- Effectiveness and Safety of Lacosamide, A Third-generation Anti-seizure Medication, for Poststroke Seizure and Epilepsy: A Literature Review.Current neuropharmacology · 2023Review
- Identification of associations and distinguishing moyamoya disease from ischemic strokes of other etiologies: A retrospective case-control study.Annals of medicine and surgery (2012) · 2022Article
- Early seizures in stroke - frequency, risk factors, and effect on patient outcomes in a tertiary center in Saudi Arabia.Neurosciences (Riyadh, Saudi Arabia) · 2022Article
- Interictal epileptiform discharges as a predictive biomarker for recurrence of poststroke epilepsy.Brain communications · 2022Article
- Assessment of the incidence and risk factors of early poststroke seizures in Lebanese patients.Brain and behavior · 2021Observational
- Risk of Developing Epilepsy after Autoimmune Encephalitis.Brain sciences · 2021Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
background and purposeSeizures are a known complication of ischemic stroke (IS). This study assesses the long-term incidence and characteristics of poststroke seizures in a well-defined population.
methodsUsing the Rochester Epidemiology Project medical records-linkage system, we identified all incident cases of IS among Rochester, Minnesota, residents from 1990 to 1994 and followed the patients in the comprehensive medical record through March 2014. All patients with poststroke seizures were identified, and data regarding incident IS, seizures, and status at last follow-up were analyzed.
resultsWe identified 489 patients with first IS. Mean follow-up was 6.5 (standard deviation 6.3) years. New onset seizures occurred in 35 patients (7.2%). Patients with poststroke seizure did not differ from those without in terms of IS etiologic subtype (P = .44) or IS risk factors (P > .05). Early seizures (within 14 days of index stroke) developed in 14 patients (40%), the majority within the first 24 hours (n = 9, 64.3%). The median time of seizure onset for the remaining 21 patients was 13.8 months. Functional outcome, as measured by modified Rankin Scale (mRS), was worse following development of poststroke seizures (mean mRS score 2.9 after IS, 3.3 following index seizure; P = .005), and mortality was higher as well, even after adjusting for IS etiologic subtype (HR 1.52, 95% confidence interval 1.07-2.16, P = .02).
conclusionDevelopment of poststroke seizures is an infrequent but significant complication of IS, portending a worse short-term functional outcome and a higher long-term mortality rate. Seizure occurrence did not differ based on IS etiologic subtype or stroke risk factors.
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