ReviewVirchows Archiv : an international journal of pathology2016
The many faces of small B cell lymphomas with plasmacytic differentiation and the contribution of MYD88 testing.
Review in Virchows Archiv : an international journal of pathology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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Who cites it
38 citing papers in PubMed, 114 citations in OpenAlex.
- Diagnostic challenges posed by the wide morphological and immunophenotypic spectrum of plasma cell neoplasms.Blood research · 2026Review
- Solitary Pancreatic Extramedullary Plasmacytoma Diagnosed Through Endoscopic Ultrasound-Guided Fine-Needle Biopsy-The Role of Endoscopic Diagnosis and Multidisciplinary Approach: A Case Report and Literature Review.Diagnostics (Basel, Switzerland) · 2026Article
- MYD88L265P mutation is a highly specific marker for the nonGCB/ABC DLBCL molecular subtype.Virchows Archiv : an international journal of pathology · 2026Article
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- CCL19bioRxiv : the preprint server for biology · 2026Article
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- Advances in the Pathogenesis, Diagnosis, Treatment, and Prognosis of Marginal Zone Lymphoma.Current treatment options in oncology · 2025Review
- Hematological entities with plasmacytic differentiation: a case report.Journal of medical case reports · 2023Article
- Leukemic Involvement Is a Common Feature in Waldenström Macroglobulinemia at Diagnosis.Cancers · 2023Article
- Crystal-Storing Histiocytosis: The Iceberg of More Serious Conditions.Diagnostics (Basel, Switzerland) · 2023Review
- Genomic landscape of mature B-cell non-Hodgkin lymphomas - an appraisal from lymphomagenesis to drug resistance.Journal of the Egyptian National Cancer Institute · 2022Review
- Article
- Monoclonal plasma cells with normal phenotype can lead to diagnosis of small B-cell lymphoma.EJHaem · 2022Article
- Relevance of Additional Immunohistochemical Markers in the Differential Diagnosis of Small B-Cell Lymphomas: A Case-Control StudyTurkish journal of haematology : official journal of Turkish Society of Haematology · 2022Article
- Towards precision medicine in lymphoid malignancies.Journal of internal medicine · 2022Review
- The 5th edition of the World Health Organization Classification of Haematolymphoid Tumours: Lymphoid Neoplasms.Leukemia · 2022Review
- Concomitant lymphoplasmacytic lymphoma, multiple myeloma, and amyloidosis: A diagnostic and therapeutic challenge.Clinical case reports · 2022Article
- Marginal zone lymphoma: present status and future perspectives.Haematologica · 2022Article
- The pathologic diagnosis of mantle cell lymphoma.Histology and histopathology · 2021Review
- Increased complexity of t(11;14) rearrangements in plasma cell neoplasms compared with mantle cell lymphoma.Genes, chromosomes & cancer · 2021Article
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Authors and funding
10 authors at 10 institutions in 8 countries.
Funding
Abstract
Plasmacytic differentiation may occur in almost all small B cell lymphomas (SBLs), although it varies from being uniformly present (as in lymphoplasmacytic lymphoma (LPL)) to very uncommon (as in mantle cell lymphomas (MCLs)). The discovery of MYD88 L265P mutations in the vast majority of LPLs has had a major impact on the study of these lymphomas. Review of the cases contributed to the 2014 European Association for Haematopathology/Society for Hematopathology slide workshop illustrated how mutational testing has helped refine the diagnostic criteria for LPL, emphasizing the importance of identifying a clonal monotonous lymphoplasmacytic population and highlighting how LPL can still be diagnosed with extensive nodal architectural effacement, very subtle plasmacytic differentiation, follicular colonization, or uncommon phenotypes such as CD5 or CD10 expression. MYD88 L265P mutations were found in 11/11 LPL cases versus only 2 of 28 other SBLs included in its differential diagnosis. Mutational testing also helped to exclude other cases that would have been considered LPL in the past. The workshop also highlighted how plasmacytic differentiation can occur in chronic lymphocytic leukemia/small lymphocytic lymphoma, follicular lymphoma, SOX11 negative MCL, and particularly in marginal zone lymphomas, all of which can cause diagnostic confusion with LPL. The cases also highlighted the difficulty in distinguishing lymphomas with marked plasmacytic differentiation from plasma cell neoplasms. Some SBLs with plasmacytic differentiation can be associated with amyloid, other immunoglobulin deposition, or crystal-storing histiocytosis, which may obscure the underlying neoplasm. Finally, although generally indolent, LPL may transform, with the workshop cases suggesting a role for TP53 abnormalities.
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