ArticleWorld journal of pediatrics : WJP2015
Intestinal detoxification time of hand-foot-and-mouth disease in children with EV71 infection and the related factors.
Article in World journal of pediatrics : WJP, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 8 citations in OpenAlex.
- Modeling human enterovirus A71 infection using an intestinal microphysiological system.Journal of virology · 2026Article
- Propolis as a Treatment Option for Hand, Foot, and Mouth Disease (HFMD) in Children: A Prospective Randomized Clinical Study.Children (Basel, Switzerland) · 2025Article
- Coxsackievirus B3 HFMD animal models in Syrian hamster and rhesus monkey.Virologica Sinica · 2024Article
- Dynamic changes of viral load and the duration of viral shedding in patients with hand, foot and mouth disease: a protocol for longitudinal study.BMC infectious diseases · 2022Article
- Article
- Seroepidemiology of echovirus 30 in Korean children.World journal of pediatrics : WJP · 2017Article
- Enterovirus 71 infection impairs the reproductive capacity of female mice.Experimental and therapeutic medicine · 2017Article
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Authors and funding
6 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundHand-foot-and-mouth disease (HFMD) is a common pediatric infectious disease caused by a variety of intestinal viruses. Enterovirus 71 (EV71) is the primary pathogen that might cause severe symptoms and even death in children with HFMD. This study aimed to investigate the intestinal detoxification time of HFMD children with EV71 infection and its related factors.
methodsSixty-five HFMD children with EV71 infection were followed up. Their stool samples were collected once every 4 to 7 days. Viral nucleic acids were detected by fluorescent polymerase chain reaction until the results became negative. The positive rates of viral nucleic acids were analyzed by the Kaplan-Meier method. The Log-rank test and Cox-Mantel test were used to analyze factors affecting the HFMD children with EV71 infection.
resultsOn the 2nd, 4th, 6th and 10th week, the positive rates of viral nucleic acids in stool samples of the 65 children were 94.6%, 48.1%, 17.2% and 0, respectively. Univariate analysis showed that the intestinal detoxification time of the children were related to gender, pre-admission disease course, severity of disease, and use of steroids or gamma globulin (P<0.05). Multivariate analysis showed that the severity of disease was an independent factor affecting the intestinal detoxification time (P<0.05), with a relative risk of 2.418.
conclusionsThe longest intestinal detoxification time of HFMD children with EV71 infection was 10 weeks. The severity of disease was an important factor affecting the intestinal detoxification time of HFMD children with EV71 infection. Severe HFMD children with EV71 infection had a longer intestinal detoxification time.
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