Evidence map›Paper›PMID 26454094›Full record

ArticleBriefings in bioinformatics2016

Pathway Tools version 19.0 update: software for pathway/genome informatics and systems biology.

Peter D Karp, Mario Latendresse, Suzanne M Paley, Markus Krummenacker, Quang D Ong, Richard Billington, Anamika Kothari, Daniel Weaver, Thomas Lee, Pallavi Subhraveti and 4 more

Abstract read
In one paragraph

Article in Briefings in bioinformatics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 154 papers.

0numbers the graph read from it
0cells of the map it votes in
154citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

154 citing papers in PubMed.

  1. Review
  2. The EcoCyc database (2025).EcoSal Plus · 2025
    Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Proteomic profiling of zinc homeostasis mechanisms inbioRxiv : the preprint server for biology · 2025
    Article
  12. Article
  13. Isolation and characterization of aApplied and environmental microbiology · 2024
    Article
  14. Review
  15. Article
  16. The Comparative Genome Dashboard.bioRxiv : the preprint server for biology · 2024
    Article
  17. Review
  18. Article
  19. The Comparative Genome Dashboard.Frontiers in microbiology · 2024
    Article
  20. The EcoCyc Database (2023).EcoSal Plus · 2023
    Review

94 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Peter D Karp
Mario Latendresse
Suzanne M Paley
Markus Krummenacker
Quang D Ong
Richard Billington
Anamika Kothari
Daniel Weaver
Thomas Lee
Pallavi Subhraveti
Aaron Spaulding
Carol Fulcher
Ingrid M Keseler
Ron Caspi

Funding

The MetaCyc & BioCyc Pathway/Genome Databases (SRI Proposal ECU 14-630)R01GM080746 · NIGMS · SRI INTERNATIONAL · PI CASPI, RON, KARP, PETER D · 2007 to 2021
$15.6M
The EcoCyc Model Organism Database for Escherichia coli [SRI Proposal ECU 14-631]U24GM077678 · NIGMS · SRI INTERNATIONAL · PI KARP, PETER D · 2006 to 2018
$12.3M
Robust Software Components for Model Organism DatabasesR01GM075742 · NIGMS · SRI INTERNATIONAL · PI KARP, PETER D · 2005 to 2019
$12.0M
NIGMS NIH HHS R01 GM075742NIGMS NIH HHS R01 GM080746NIGMS NIH HHS U24 GM077678
6 · The paper itself

Abstract

Pathway Tools is a bioinformatics software environment with a broad set of capabilities. The software provides genome-informatics tools such as a genome browser, sequence alignments, a genome-variant analyzer and comparative-genomics operations. It offers metabolic-informatics tools, such as metabolic reconstruction, quantitative metabolic modeling, prediction of reaction atom mappings and metabolic route search. Pathway Tools also provides regulatory-informatics tools, such as the ability to represent and visualize a wide range of regulatory interactions. This article outlines the advances in Pathway Tools in the past 5 years. Major additions include components for metabolic modeling, metabolic route search, computation of atom mappings and estimation of compound Gibbs free energies of formation; addition of editors for signaling pathways, for genome sequences and for cellular architecture; storage of gene essentiality data and phenotype data; display of multiple alignments, and of signaling and electron-transport pathways; and development of Python and web-services application programming interfaces. Scientists around the world have created more than 9800 Pathway/Genome Databases by using Pathway Tools, many of which are curated databases for important model organisms.

Indexed as

GenomeComputational BiologyGenomicsInternetMetabolic Networks and PathwaysSoftware DesignSystems Biologycomputational genomicsmetabolic modelsmetabolic pathwayssystems biology

Identifiers

PMID26454094
PMCPMC5036846

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.