ArticleHuman brain mapping2016
Brain network analysis reveals affected connectome structure in bipolar I disorder.
Article in Human brain mapping, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
45 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Psychoradiological patterns of small-world properties and a systematic review of connectome studies of patients with 6 major psychiatric disordersJournal of psychiatry & neuroscience : JPN · 2018Pooled it
- Changes in the structural brain connectome over the course of a nonrandomized clinical trial for acute mania.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2022Trial
- Changes in the brain structural connectome after a prospective randomized clinical trial of lithium and quetiapine treatment in youth with bipolar disorder.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2021Trial
- Moral emotion processing in euthymic bipolar disorder: insights from network analysis.European archives of psychiatry and clinical neuroscience · 2026Article
- Effects of sleep on the glymphatic functioning and multimodal human brain network affecting memory in older adults.Molecular psychiatry · 2025Article
- Common and disease-specific patterns of functional connectivity and topology alterations across unipolar and bipolar disorder during depressive episodes: a transdiagnostic study.Translational psychiatry · 2025Article
- Provincial and connector qualities of somatosensory brain network hubs in bipolar disorder.Cerebral cortex (New York, N.Y. : 1991) · 2024Article
- Age Trajectories of the Structural Connectome in Child and Adolescent Offspring of Individuals With Bipolar Disorder or Schizophrenia.Biological psychiatry global open science · 2024Article
- Innovative Neuroimaging Biomarker Distinction of Major Depressive Disorder and Bipolar Disorder through Structural Connectome Analysis and Machine Learning Models.Diagnostics (Basel, Switzerland) · 2024Article
- Weighting the structural connectome: Exploring its impact on network properties and predicting cognitive performance in the human brain.Network neuroscience (Cambridge, Mass.) · 2024Article
- Genetic, individual, and familial risk correlates of brain network controllability in major depressive disorder.Molecular psychiatry · 2023Article
- Classification of Contrasting Discrete Emotional States Indicated by EEG Based Graph Theoretical Network Measures.Neuroinformatics · 2022Article
- Aberrant Subnetwork and Hub Dysconnectivity in Adult Bipolar Disorder: A Multicenter Graph Theory Analysis.Cerebral cortex (New York, N.Y. : 1991) · 2022Article
- Modular-Level Functional Connectome Alterations in Individuals With Hallucinations Across the Psychosis Continuum.Schizophrenia bulletin · 2022Article
- Alteration of cortical functional networks in mood disorders with resting-state electroencephalography.Scientific reports · 2022Article
- The impact of graph construction scheme and community detection algorithm on the repeatability of community and hub identification in structural brain networks.Human brain mapping · 2021Article
- Functional connectome differences in individuals with hallucinations across the psychosis continuum.Scientific reports · 2021Article
- Structural Differences Between Healthy Subjects and Patients With Schizophrenia or Schizoaffective Disorder: A Graph and Control Theoretical Perspective.Frontiers in psychiatry · 2021Article
- Predicting MEG resting-state functional connectivity from microstructural information.Network neuroscience (Cambridge, Mass.) · 2021Article
- The R1-weighted connectome: complementing brain networks with a myelin-sensitive measure.Network neuroscience (Cambridge, Mass.) · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
Abstract
The notion that healthy brain function emerges from coordinated neural activity constrained by the brain's network of anatomical connections--i.e., the connectome--suggests that alterations in the connectome's wiring pattern may underlie brain disorders. Corroborating this hypothesis, studies in schizophrenia are indicative of altered connectome architecture including reduced communication efficiency, disruptions of central brain hubs, and affected "rich club" organization. Whether similar deficits are present in bipolar disorder is currently unknown. This study examines structural connectome topology in 216 bipolar I disorder patients as compared to 144 healthy controls, focusing in particular on central regions (i.e., brain hubs) and connections (i.e., rich club connections, interhemispheric connections) of the brain's network. We find that bipolar I disorder patients exhibit reduced global efficiency (-4.4%, P =0.002) and that this deficit relates (r = 0.56, P < 0.001) to reduced connectivity strength of interhemispheric connections (-13.0%, P = 0.001). Bipolar disorder patients were found not to show predominant alterations in the strength of brain hub connections in general, or of connections spanning brain hubs (i.e., "rich club" connections) in particular (all P > 0.1). These findings highlight a role for aberrant brain network architecture in bipolar I disorder with reduced global efficiency in association with disruptions in interhemispheric connectivity, while the central "rich club" system appears not to be particularly affected.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.