Evidence map›Paper›PMID 26453955›Full record

ArticleClinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association2016

Effects of Gluten Intake on Risk of Celiac Disease: A Case-Control Study on a Swedish Birth Cohort.

Carin Andrén Aronsson, Hye-Seung Lee, Sibylle Koletzko, Ulla Uusitalo, Jimin Yang, Suvi M Virtanen, Edwin Liu, Åke Lernmark, Jill M Norris, Daniel Agardh and 1 more

Registry-linked trialOpen access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04593888 (Gluten Reduction After Infancy and Risk of Celiac Disease), which is not on this map. Cited by 49 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
49citing papers in PubMed, 3 pooled it
10.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04593888 naactive not recruitingnot on this mapstarted 2021, after this paper: background citation

Gluten Reduction After Infancy and Risk of Celiac Disease

TypeinterventionalSponsorLund UniversityRan2021 to 2035Enrolled1,141ConditionsCeliac Disease in Children, Autoimmune Diseases, type1diabetesArmsGluten reduced diet
3 · Its place in the literature

Who cites it

49 citing papers in PubMed, 3 syntheses or guidelines pooled it, 118 citations in OpenAlex.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors at 7 institutions in 4 countries.

Carin Andrén AronssonDepartment of Clinical Sciences, Lund University, Skåne University Hospital, Malmö, Sweden.
Hye-Seung LeeHealth Informatics Institute, Morsani College of Medicine, University of South Florida, Tampa, Florida.
Sibylle KoletzkoDr. von Hauner Children's Hospital, Ludwig Maximilians University, Munich, Germany.
Ulla UusitaloHealth Informatics Institute, Morsani College of Medicine, University of South Florida, Tampa, Florida.
Jimin YangHealth Informatics Institute, Morsani College of Medicine, University of South Florida, Tampa, Florida.
Suvi M VirtanenNational Institute for Health and Welfare, Nutrition Unit, Helsinki, Finland; School of Health Sciences, University of Tampere, Finland; Research Center for Child Health, Tampere University and University Hospital, Science Center of Pirkanmaa Hospital District, University of Tampere, Finland.
Edwin LiuDigestive Health Institute, Children's Hospital Colorado, University of Colorado Denver, Aurora, Colorado.
Åke LernmarkDepartment of Clinical Sciences, Lund University, Skåne University Hospital, Malmö, Sweden.
Jill M NorrisDepartment of Epidemiology, Colorado School of Public Campus, University of Colorado Denver, Aurora, Colorado.
Daniel AgardhDepartment of Clinical Sciences, Lund University, Skåne University Hospital, Malmö, Sweden. Electronic address: daniel.agardh@med.lu.se.
TEDDY Study Group
University of South Florida · USLund University · SEChildren's Hospital Colorado · USSkåne University Hospital · SEColorado School of Public Health · USLudwig-Maximilians-Universität München · DETampere University · FI

Funding

Data Coordinating Center (DCC)for the Consortium for Identification of EnvironmenUC4DK095300 · NIDDK · UNIVERSITY OF SOUTH FLORIDA · PI KRISCHER, JEFFREY P · 2011 to 2011
$56.0M
Data Coordinating CenterU01DK063790 · NIDDK · UNIVERSITY OF SOUTH FLORIDA · PI KRISCHER, JEFFREY P · 2002 to 2006
$50.1M
Colorado Clinical and Translational Sciences InstituteUL1TR001082 · NCATS · UNIVERSITY OF COLORADO DENVER · PI SOKOL, RONALD J. · 2013 to 2017
$48.0M
Using social networks to map and evaluate team science across CTSA hubsUL1TR001427 · NCATS · UNIVERSITY OF FLORIDA · PI MITCHELL, DUANE A. · 2015 to 2024
$37.2M
NIDDK Follow-up on Subjects and Immunological Assessments in The Environmental Determinants of Diabetes In The Young Study (TEDDY) (UC4)UC4DK117483 · NIDDK · UNIVERSITY OF SOUTH FLORIDA · PI KRISCHER, JEFFREY P · 2017 to 2020
$30.4M
Establish a Data Coordinating Center (DCC) for the Consortium for Identification UC4DK100238 · NIDDK · UNIVERSITY OF SOUTH FLORIDA · PI KRISCHER, JEFFREY P · 2014 to 2014
$28.9M
The Study of Epigenetics and Infections in The Environmental Determinants of Diabetes in the Young (TEDDY)UC4DK112243 · NIDDK · UNIVERSITY OF SOUTH FLORIDA · PI KRISCHER, JEFFREY P · 2016 to 2016
$27.0M
Data Coordinating Center (DCC) for the Consortium for Identification of Environmental Determinants of Diabetes in the Young (TEDDY) StudyUC4DK106955 · NIDDK · UNIVERSITY OF SOUTH FLORIDA · PI KRISCHER, JEFFREY P · 2015 to 2015
$20.0M
The Environmental Determinants of Diabetes in Young (TEDDY0U01DK063863 · NIDDK · HOSPITAL DISTRICT OF SOUTHWEST FINLAND · PI TOPPARI, JORMA · 2003 to 2022
$13.5M
The Environmental Triggers of Diabetes (TEDDY) in SwedenU01DK063861 · NIDDK · UNIVERSITY OF WASHINGTON · PI LERNMARK, AKE · 2003 to 2022
$13.4M
THE TEDDY STUDY - COLORADO CLINICAL CENTERU01DK063821 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI REWERS, MARIAN J · 2003 to 2022
$12.3M
The TEDDY Study: Georgia/Florida Clinical CenterU01DK063865 · NIDDK · MEDICAL COLLEGE OF GEORGIA (MCG) · PI MCINDOE, RICHARD A. · 2003 to 2022
$12.3M
NCATS NIH HHS UL1 TR000064NCATS NIH HHS UL1 TR001082NCATS NIH HHS UL1 TR001427NIDDK NIH HHS HHSN267200700014CNIDDK NIH HHS U01 DK063790NIDDK NIH HHS U01 DK063821NIDDK NIH HHS U01 DK063829NIDDK NIH HHS U01 DK063836NIDDK NIH HHS U01 DK063861NIDDK NIH HHS U01 DK063863NIDDK NIH HHS U01 DK063865NIDDK NIH HHS U01 DK63790NIDDK NIH HHS U01 DK63821NIDDK NIH HHS U01 DK63829NIDDK NIH HHS U01 DK63836NIDDK NIH HHS U01 DK63861NIDDK NIH HHS U01 DK63863NIDDK NIH HHS U01 DK63865NIDDK NIH HHS UC4 DK063821NIDDK NIH HHS UC4 DK063829NIDDK NIH HHS UC4 DK063836NIDDK NIH HHS UC4 DK063861NIDDK NIH HHS UC4 DK063863NIDDK NIH HHS UC4 DK063865NIDDK NIH HHS UC4 DK095300NIDDK NIH HHS UC4 DK100238NIDDK NIH HHS UC4 DK106955NIDDK NIH HHS UC4 DK112243NIDDK NIH HHS UC4 DK117483NIDDK NIH HHS UC4 DK63821NIDDK NIH HHS UC4 DK63829NIDDK NIH HHS UC4 DK63836NIDDK NIH HHS UC4 DK63861NIDDK NIH HHS UC4 DK63863NIDDK NIH HHS UC4 DK63865NIDDK NIH HHS UC4 DK95300
6 · The paper itself

Abstract

BACKGROUND &

aimsEarly nutrition may affect the risk of celiac disease. We investigated whether amount of gluten in diet until 2 years of age increases risk for celiac disease.

methodsWe performed a 1-to-3 nested case-control study of 146 cases, resulting in 436 case-control pairs matched for sex, birth year, and HLA genotype generated from Swedish children at genetic risk for celiac disease. Newborns were annually screened for tissue transglutaminase autoantibodies (tTGA). If tested tTGA positive, time point of seroconversion was determined from frozen serum samples taken every 3 months. Celiac disease was confirmed by intestinal biopsies. Gluten intake was calculated from 3-day food records collected at ages 9, 12, 18 and 24 months. Odds ratios (OR) were calculated through conditional logistic regression.

resultsBreastfeeding duration (median, 32 wk) and age at first introduction to gluten (median, 22 wk) did not differ between cases and tTGA-negative controls. At the visit before tTGA seroconversion, cases reported a larger intake of gluten than controls (OR, 1.28; 95% confidence interval [CI], 1.13-1.46; P = .0002). More cases than controls were found in the upper third tertile (ie, >5.0 g/d) before they tested positive for tTGA seroconversion than controls (OR, 2.65; 95% CI, 1.70-4.13; P < .0001). This finding was similar in children homozygous for DR3-DQ2 (OR, 3.19; 95% CI, 1.61-6.30; P = .001), heterozygous for DR3-DQ2 (OR, 2.24; 95% CI, 1.08-4.62; P = .030), and for children not carrying DR3-DQ2 (OR, 2.43; 95% CI, 0.90-6.54; P = .079).

conclusionsThe amount of gluten consumed until 2 years of age increases the risk of celiac disease at least 2-fold in genetically susceptible children. These findings may be taken into account for future infant feeding recommendations.

Indexed as

AutoantibodiesBiopsyCase-Control StudiesCeliac DiseaseChildChild, PreschoolDietFemaleGlutensGTP-Binding ProteinsHumansInfantIntestinesMaleProtein Glutamine gamma Glutamyltransferase 2Risk AssessmentAutoantibodiesGlutensGTP-Binding ProteinsProtein Glutamine gamma Glutamyltransferase 2TransglutaminasesDietPediatricTEDDY StudyWheat

Identifiers

PMID26453955
PMCPMC4897964
OpenAlexW2288151404

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.