ArticleSchizophrenia bulletin2016
The Core Brain Region for Face Processing in Schizophrenia Lacks Face Selectivity.
Article in Schizophrenia bulletin, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 2 of them syntheses that pooled it.
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Who cites it
12 citing papers in PubMed, 2 syntheses or guidelines pooled it, 19 citations in OpenAlex.
- A Systematic Review and Meta-Analysis on Contrast Sensitivity in Schizophrenia.Schizophrenia bulletin · 2025Pooled it
- Neural circuit disruptions of eye gaze processing in autism spectrum disorder and schizophrenia: An activation likelihood estimation meta-analysis.Schizophrenia research · 2024Pooled it
- Altered brain dynamics of facial emotion processing in schizophrenia: a combined EEG/fMRI study.Schizophrenia (Heidelberg, Germany) · 2025Article
- Impaired Filtering and Hyperfocusing: Neural Evidence for Distinct Selective Attention Abnormalities in People with Schizophrenia.Cerebral cortex (New York, N.Y. : 1991) · 2022Article
- An Event-Related Potential Investigation of Early Visual Processing Deficits During Face Perception in Youth at Clinical High Risk for Psychosis.Schizophrenia bulletin · 2022Article
- Mapping Progressive Gray Matter Alterations in Early Childhood Autistic Brain.Cerebral cortex (New York, N.Y. : 1991) · 2021Article
- Stable habituation deficits in the early stage of psychosis: a 2-year follow-up study.Translational psychiatry · 2021Article
- Cortical Pathways or Mechanism in the Face Inversion Effect in Patients with First-Episode Schizophrenia.Neuropsychiatric disease and treatment · 2021Article
- Influence of More Than 5 Years of Continuous Exposure to Antipsychotics on Cerebral Functional Connectivity of Chronic Schizophrenia.Canadian journal of psychiatry. Revue canadienne de psychiatrie · 2020Article
- Revealing the Dysfunction of Schematic Facial-Expression Processing in Schizophrenia: A Comparative Study of Different References.Frontiers in neuroscience · 2017Article
- Deficient cortical face-sensitive N170 responses and basic visual processing in schizophrenia.Schizophrenia research · 2016Article
- Sluggishness of Early-Stage Face Processing (N170) Is Correlated with Negative and General Psychiatric Symptoms in Schizophrenia.Frontiers in human neuroscience · 2016Article
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Authors and funding
5 authors at 2 institutions in 1 country.
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Abstract
backgroundFace perception impairment in schizophrenia has long been recognized. However, brain mechanisms underlying this socially important perceptual deficit are not well understood. Previous magnetic resonance imaging (MRI) studies have shown that patients have altered structure in brain regions responsible for processing face information, but functional properties of these brain regions are not clearly determined. A key functional property of the face-processing system--face selectivity--has yet to be evaluated in schizophrenia.
methodsWe used functional MRI (fMRI) to examine face selectivity of 3 core face-processing regions--fusiform face area (FFA), occipital face area (OFA), and superior temporal sulcus (STS)--in schizophrenia patients (n = 24) and healthy controls (n = 23). To disassociate face-specific processing from general perceptual processing, we compared cortical activations during performance of perceptually equated face and tree detection tasks.
resultsActivation levels of the 3 putative face-processing regions during face detection did not differ between patients and controls, being similar for FFA and OFA and absent for STS. However, face selectivity, indexed by the difference in cortical activation between face and tree detection, was significantly reduced in patients for FFA, especially for low-contrast stimuli. FFA activation and perceptual performance during face detection were associated in patients.
conclusionsThese results show a lack of face-specific processing in the schizophrenic brain region presumably subserving face perception. This finding suggests boosting visual salience of face images as a potential therapeutic venue for improving face perception in this psychiatric disorder.
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